DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Skap2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_061243.1	Gene:	Skap2 / 54353	MGIID:	1889206	Length:	358	Species:	Mus musculus

Alignment Length:	295	Identity:	58/295 - (19%)
Similarity:	104/295 - (35%)	Gaps:	112/295 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 PQDVAHFL----------YKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQF 481
            |:::.:.|          .|||.|:|.|        .:..|.::|   .:.|..::        :
Mouse    14 PEEIRNLLADVETFVADTLKGENLSKKA--------KEKRESLIK---KIKDVKSV--------Y 59

  Fly   482 LWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQ 546
            |..|:..|:|:..|...:.||      .|     .||..:.|                     ::
Mouse    60 LQEFQDKGDAEDGDEYDDPFA------GP-----ADTISLAS---------------------ER 92

  Fly   547 FISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYK--- 608
            :...:.|.::|...|....:.|       ||.|                |.|:|.|:...:.
Mouse    93 YDKDDDGPSDGNQFPPIAAQDL-------PFVI----------------KAGYLEKRRKDHSFLG 134

  Fly   609 -SWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIH----DRSKPHCFELFATGGADIIK 668
             .|::||..|:....||:....||:.:|...::...||..:    |..|..|||:
Mouse   135 FEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYDVRMNNTLRKDGKKDCCFEI---------- 189

  Fly   669 ACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRL 703
             |..|..         :|:.:||:.:|.:||:::|
Mouse   190 -CAPDKR---------IYQFTAASPKDAEEWVQQL 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	26/159 (16%)
		PH_GRP1-like	592..710	CDD:269954	29/120 (24%)
		PH	596..708	CDD:278594	29/116 (25%)
Skap2	NP_061243.1	Homodimerization	14..64		12/68 (18%)
		PH_Skap-hom_Skap2	117..222	CDD:270181	30/134 (22%)
		PH	117..215	CDD:278594	30/134 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..292
		SH3	300..352	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910