DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and MYO10

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_036466.2	Gene:	MYO10 / 4651	HGNCID:	7593	Length:	2058	Species:	Homo sapiens

Alignment Length:	586	Identity:	112/586 - (19%)
Similarity:	190/586 - (32%)	Gaps:	207/586 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 TTKVTEVQRLPCDEPNTEL---ISKRTEYKHTTITTTTRTLIVSRPVELL--LNENGEI-IARRS 251
            |.|..|::.|...:...||   :.|:.|.|.     ....|.:.:.:|.|  :.|..|: :...|
Human   856 TRKQQELEALQKSQKEAELTRELEKQKENKQ-----VEEILRLEKEIEDLQRMKEQQELSLTEAS 915

  Fly   252 PRK---SRSNSLGRM-----------LDVQNEIGTGGLFMEADPCSKN----------------- 285
            .:|   .|...|.|:           |:..|       |.|.|.|.:|
Human   916 LQKLQERRDQELRRLEEEACRAAQEFLESLN-------FDEIDECVRNIERSLSVGSEFSSELAE 973

  Fly   286 -----------SLP-PPPYIDDMRFIDDSS--NSQSESERNSNIHKTNKYTSKNNNNDSKRESQQ 336
                       |.| |...:|:....||.:  :|.:.||..   |...:.:....::||..|...
Human   974 SACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSEHG---HSDQRTSGIRTSDDSSEEDPY 1035

  Fly   337 SNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSI 401
            .|          ...:.|..|.:..:|..||.|....|                 |::     |.
Human  1036 MN----------DTVVPTSPSADSTVLLAPSVQDSGSL-----------------HNS-----SS 1068

  Fly   402 GRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVAL 466
            |...:.|                  ||:.        |...:..|||..:::|:.:..:.:..::
Human  1069 GESTYCM------------------PQNA--------GDLPSPDGDYDYDQDDYEDGAITSGSSV 1107

  Fly   467 HDFTNLILVQALRQFLWS-----------------FRLPGEAQKIDRMMETFAQRYCQLNPDIFT 514
             .|:|....|      ||                 |...|.....:...|.|..|: ..:.::..
Human  1108 -TFSNSYGSQ------WSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRF-DTDDELSY 1164

  Fly   515 NTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKI 579
            ..|:.|                |....|....|:.|..|:.|.       .:..:..::.|.|..
Human  1165 RRDSVY----------------SCVTLPYFHSFLYMKGGLMNS-------WKRRWCVLKDETFLW 1206

  Fly   580 PQDDGNDLMHTFFNPDKEGWLWKQGG-----RYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPL 639
            .:.....|        |:|||.|:||     ..::||:|||:|..:.|.|||..::::.:|.:.:
Human  1207 FRSKQEAL--------KQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEV 1263

  Fly   640 ENISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLT 704
            .  :.:||.|.:...       .|.|||.|.:|             :.:.|.:.||..:|...|:
Human  1264 R--TAKEIIDNTTKE-------NGIDIIMADRT-------------FHLIAESPEDASQWFSVLS 1306

  Fly   705 Q 705
            |
Human  1307 Q 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	29/196 (15%)
		PH_GRP1-like	592..710	CDD:269954	33/119 (28%)
		PH	596..708	CDD:278594	33/115 (29%)
MYO10	NP_036466.2	MYSc	58..739	CDD:214580
		MYSc_Myo10	77..727	CDD:276840
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	619..641
		SAH. /evidence=ECO:0000250\|UniProtKB:F8VQB6, ECO:0000250\|UniProtKB:P79114	815..908		13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..840
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..866		3/9 (33%)
		Mediates antiparallel dimerization. /evidence=ECO:0000269\|PubMed:23012428	883..933		12/54 (22%)
		MYO10_CC	883..933	CDD:293340	12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1090		30/186 (16%)
		PH-like	1181..>1223	CDD:302622	12/56 (21%)
		PH2_MyoX	1215..1316	CDD:270108	33/115 (29%)
		PH	1215..1308	CDD:278594	33/115 (29%)
		PH3_MyoX-like	1381..1506	CDD:270109
		PH	1396..1495	CDD:278594
		MyTH4	1549..1695	CDD:214535
		B41	1704..1958	CDD:214604
		UBQ	1705..>1753	CDD:294102
		FERM_M	1796..1958	CDD:278785
		FERM_C_MyoX	1954..2042	CDD:270023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910