DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and zap70

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001006825.1	Gene:	zap70 / 448557	XenbaseID:	XB-GENE-956409	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	264	Identity:	56/264 - (21%)
Similarity:	94/264 - (35%)	Gaps:	67/264 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 KSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDVTTKV------ 196
            |||..:|:.....|.|         .|::|   ||.:.||:.|.:.....|....|.:.
Frog   242 KSDGIMAVLKESCPNS---------CTFSI---APAAAPPSLPKIRQAASNSDGYTPEPFIGKSR 294

  Fly   197 -----TEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEI------IARR 250
                 |.|...|..:|.        |.|.       |.|.|.|  ||||.:..|:      ..::
Frog   295 ILPMDTSVYESPYSDPE--------ELKE-------RKLFVKR--ELLLIDEVELGSGNFGCVKK 342

  Fly   251 SPRKSRSNSLG---RMLDVQNEIGTGGLFM-EADPCSKNSLPPPPYIDDMRFIDDSSNSQSESER 311
            ...|.:...:.   ::|.||:|.......| ||:...:..   .|||..|..:.::.|.....|.
Frog   343 GVYKLKKRQIDVAIKVLKVQDEKNVRDEMMKEAEIMHQLD---NPYIVRMIGVCEAENLMLVMEM 404

  Fly   312 NSNIHKTNKYTSKNNNNDSKRESQQSNLCE-------SCRMLLDRNYINTE-QSDNLVILRRPSK 368
            .|. ...||:...     .|.....||:.|       ..:.|..:|:::.: .:.|::::.:...
Frog   405 ASG-GPLNKFLGA-----KKDVIPMSNIVELMHQVSIGMKYLEGKNFVHRDLAARNVLMVNQHYA 463

  Fly   369 QIKD 372
            :|.|
Frog   464 KISD 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
zap70	NP_001006825.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191
		SH2_C-SH2_Zap70	152..256	CDD:198265	4/13 (31%)
		PKc_like	321..589	CDD:389743	32/158 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910