DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment step and IQSEC3

DIOPT Version :9

Sequence 1:NP_001036375.2 Gene:step / 35425 FlyBaseID:FBgn0086779 Length:727 Species:Drosophila melanogaster
Sequence 2:NP_001164209.1 Gene:IQSEC3 / 440073 HGNCID:29193 Length:1182 Species:Homo sapiens


Alignment Length:681 Identity:160/681 - (23%)
Similarity:268/681 - (39%) Gaps:216/681 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PGLGGSE---------SVGRKQPLQRSC--------------LDLSTTRVGCDGCVSLEFFQSES 70
            ||.|.:.         |.||:||...:.              |||...::     ..||......
Human   253 PGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNKQI-----EMLEHKYGGH 312

  Fly    71 PESRRSNSTFYVNT---QNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGDRNETP 132
            ..|||:..|  :.|   |...|..|:..|..|||     ...|..:.:|           :..:|
Human   313 LVSRRAACT--IQTAFRQYQLSKNFEKIRNSLLE-----SRLPRRISLR-----------KVRSP 359

  Fly   133 T---MATPKSDIK-IALKPPPKPRSPSMAP------------YT------------SVATYNITK 169
            |   :|..|:.:: ..|...|..||||:.|            :|            :::|:::..
Human   360 TAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKT 424

  Fly   170 L-----------------------------APDS---------------PPPASPTLSTQTVNCS 190
            :                             ||:|               ||..|.||   .:...
Human   425 MCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTL---MMAFR 486

  Fly   191 DVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLI--------VSRPVELLLN--ENGE 245
            |||.::..                    ::.:::::|...:        |..|.|....  |.||
Human   487 DVTVQIAN--------------------QNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGE 531

  Fly   246 IIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPCSK-------NSLPPPPYIDDMRFIDDSS 303
            ...|.:|   .:.::||. |...|          |.|::       :....|           .:
Human   532 TSGREAP---EAPAVGRE-DASAE----------DSCAEAAASGAADGATAP-----------KT 571

  Fly   304 NSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSK 368
            ..:.|.|..:.:.:    .::....|.::.|..|...:|.:...:.:...::.:...:||..|..
Human   572 EEEEEEEETAEVGR----GAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRY 632

  Fly   369 QIKDELCEVVSEMEALDVPEDCKHSN------KDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDP 427
            .     ||         .|..||...      :.:...||...||::|.|||::|:....:...|
Human   633 H-----CE---------NPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTP 683

  Fly   428 QDVAHFLYKGEGLNKTAIGDYLG-EKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEA 491
            ..|||||.:.:||::..||::|| .|..||.|||...|...||:::.|.:|||:|....|:.|||
Human   684 IGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEA 748

  Fly   492 QKIDRMMETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHNPSVKD--KPTVDQFISMN 551
            ||::|::|.|:||||..||::   |.|.||.::|:||||:|||.:::|::|.  |..::.||...
Human   749 QKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNL 813

  Fly   552 RGINNGGDLPRGLLESLYESIRTEPFKIPQD 582
            ||:::|.|:||.|:..:||.|:.:..|..:|
Human   814 RGVDDGADIPRELVVGIYERIQQKELKSNED 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stepNP_001036375.2 Sec7 397..577 CDD:279680 77/185 (42%)
PH_GRP1-like 592..710 CDD:269954
PH 596..708 CDD:278594
IQSEC3NP_001164209.1 bZIP <32..63 CDD:269834
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..275 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..479 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..616 19/123 (15%)
Sec7 651..839 CDD:279680 77/187 (41%)
PH_IQSEC 866..996 CDD:270128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1182
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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