DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and sec73

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001342851.1	Gene:	sec73 / 3361502	PomBaseID:	SPAC19A8.01c	Length:	1082	Species:	Schizosaccharomyces pombe

Alignment Length:	578	Identity:	137/578 - (23%)
Similarity:	223/578 - (38%)	Gaps:	135/578 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SESPESRRSNSTFYVNTQNVS--SAVFKDNRQPLLE-------------RGSGSDSSPSSVCVRC 117
            |....|.:|.....||:.|.|  |:.||.:.|..|.             :.|||.:|.|    :.
pombe     7 SSQESSNKSEKDTTVNSPNASSFSSFFKKSSQTYLSKRSEKLNEHNSKLKSSGSFTSNS----QT 67

  Fly   118 SCNSITKSGDRNETPTMATPK----------SDIKIALKPPPKPRSPSMAPYTSVATYNITKLAP 172
            ..::...|..:|....:|..|          ||::.|..|        :|.|:|.:..|.:....
pombe    68 DLSNSPSSKKKNIFYPIARAKHSFYFNHNWSSDLQQANSP--------VASYSSQSVSNDSNFPK 124

  Fly   173 DSPPPASPTLSTQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTEYK---------HTTITTTTR 228
            |...|.|..||....:.           :.|....:.:|.:.|:.::         :..:.:||
pombe   125 DVTSPISTDLSGSNPSL-----------KSPSSINSAKLRASRSFFRFPKWSRKSWNPDVNSTT- 177

  Fly   229 TLIVSRPVELLLNENGEIIARRSPRKSRSNSLGRMLD---VQNEIGTGGLFMEADPCSKN--SLP 288
                |.|.|:     |.:.....|...::.:|....|   :||  ||....::.....|.  |||
pombe   178 ----SSPSEV-----GSLDKAGGPLNQQNENLSAESDNTILQN--GTRKSSVKMSDLGKRIASLP 231

  Fly   289 ----PP-------PYIDDMRFIDDSSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLCE- 341
                ||       .||..:...|.:||..|.|   |::.....|.|.:..||.::...||:...
pombe   232 VVKRPPIQFSISSDYIKPVDKSDQTSNVPSPS---SSVGSLRLYRSPSIPNDVEQPQPQSSRSRP 293

  Fly   342 -----SCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSI 401
                 ..:..|:|...|.....:...|||     .|:.| |...:|...:..|.|
pombe   294 RSSTIPTQRTLERLRENRSSIFSFRTLRR-----DDDEC-VAQTIENSALFSDIK---------- 342

  Fly   402 GRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVAL 466
                  .:|.|.:..:.|   |..|....::.....|.:..:.:...|.||     |.:....||
pombe   343 ------PNPTKFLSSVPE---LTADDTAESYLSKLRETVPYSRMIPVLAEK-----DHVTLNKAL 393

  Fly   467 H------DFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFA 525
            |      :|.|..|...||.||....||.|.|:|||::..|::||.:.||.:|::.|.||:|.|:
pombe   394 HLCMSGMEFENRPLDFCLRLFLLKSHLPKETQQIDRVINAFSKRYFECNPGMFSSQDQCYILVFS 458

  Fly   526 IIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDD 583
            ::||:|.:.|.:.|.|.|..:||:    :.:..:|...::|..|::|...|| :..||
pombe   459 LMMLHTDVFNSNNKHKMTKQEFIN----LCDIDELAPEIMEYYYDNITFTPF-VNLDD 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	51/185 (28%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
sec73	NP_001342851.1	COG3942	5..>222	CDD:332523	50/249 (20%)
		Sec7	<381..506	CDD:307500	45/133 (34%)
		PH	<710..767	CDD:214574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000