DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and AgaP_AGAP000124

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_566290.4	Gene:	AgaP_AGAP000124 / 3289620	VectorBaseID:	AGAP000124	Length:	1416	Species:	Anopheles gambiae

Alignment Length:	596	Identity:	118/596 - (19%)
Similarity:	191/596 - (32%)	Gaps:	214/596 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 STFYVNTQNVSSAVFKDNRQPLLE-----RGSGSDSSPSSVCVRCSCNSITKSGDRNETPTMATP 137
            |.|...||.:.:.   |.:.|.||     .|...|..|.   ||.|     |||      |:|.|
Mosquito   654 SPFKKITQQLGAL---DLKSPELEDFSTPMGPAPDLWPQ---VRTS-----KSG------TLAVP 701

  Fly   138 KSDIKIALKPPPKPRSPSMAPYTSVATY--NITKLAPD----------SPPPASPTLSTQTVNCS 190
            ::      |||..|..||:....::||.  :.::|..|          |...|..||.:...
Mosquito   702 RA------KPPVVPSPPSLDLSDTIATIQSSFSQLQQDGAEGEQSGHGSQAAAPYTLPSPCY--- 757

  Fly   191 DVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKS 255
                       ||.::|:|...:|.:......:|.:          |...:.|||:.....|
Mosquito   758 -----------LPTEQPSTSKANKLSTGGGGAVTFS----------ETHFDINGEVTLSHVP--- 798

  Fly   256 RSNSLGRMLDVQNEIGTGGLFMEADPCSKNSL--PPPPYIDDMRFIDDSSNS-----QSESERNS 313
                                  ...|..|.:.  .|||.:..:..:..|:.:     ::::|..|
Mosquito   799 ----------------------PTVPAMKPAAGSEPPPQLASLPNMGSSTLTANQLLENKNELLS 841

  Fly   314 NIHKTNKYTSKN-----NNNDSKRESQQSNLCESCRML--------LDRNYINTEQS-------- 357
            |::....|..:|     .:|.:..:::..:...|....        ||...:|.|.|
Mosquito   842 NVYDEQGYLIENTAIVLGHNGAFLDTKVMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLVSKV 906

  Fly   358 -------------------DNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGR 403
                               ..|..|:||:.  .:.|...|...:.|.:|:....:....:.:.||
Mosquito   907 KFLCGRCGSPAVRLRAPKGSTLGTLQRPTS--IETLQTYVVTSQPLSLPQAAGAAESVSKPAAGR 969

  Fly   404 KKFNMDPKK-----------------GIEYLVE-----------NRLLRHDPQDVAHFLYKG--- 437
            :   .||.:                 |||....           |..|.....:||..:.||
Mosquito   970 E---ADPAQEEQTPPTPATISDVALCGIEMKATAPPSLSTSKELNLALTQAVGEVARKVKKGNKF 1031

  Fly   438 -EGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMME-- 499
             :||:.:|..|:..|   ....:.|            |.||:...|.:.||....|::.:.|.
Mosquito  1032 TDGLDLSATTDWALE---LRPSMKK------------LRQAMDGLLKTARLMHSVQRLQQDMRKT 1081

  Fly   500 --TFAQRYCQLNPDIFTNTDTCY--VLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDL 560
              |.|..|         ..|.|:  .|:..:..|...|...:|     .:.|||:   :.:.|.|
Mosquito  1082 SATLAIMY---------RRDVCFSQALTSLVAGLMAKLWGQNV-----TENFISV---LVHLGPL 1129

  Fly   561 P--RGLLESLY 569
            .  .||| |||
Mosquito  1130 AYFEGLL-SLY 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	47/213 (22%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
AgaP_AGAP000124	XP_566290.4	PH_INPP4A_INPP4B	1..146	CDD:270091
		PH	30..119	CDD:278594
		C2	167..277	CDD:301316
		Pollen_allerg_1	989..>1052	CDD:298693	14/65 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910