DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and cyth1b

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_005169523.1	Gene:	cyth1b / 325586	ZFINID:	ZDB-GENE-030131-4311	Length:	416	Species:	Danio rerio

Alignment Length:	382	Identity:	252/382 - (65%)
Similarity:	311/382 - (81%)	Gaps:	8/382 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 INTEQSDNLVILRRPSKQ-------IKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMD 409
            :..|:...|..:||..::       :|||:.:|.:|:|.|...::..:..:.|||::||||||||
Zfish    31 LTPEEKQELENIRRRKQELLEDIQRLKDEITKVTNEIECLGSTQERINMQRSKQMAMGRKKFNMD 95

  Fly   410 PKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLIL 474
            |||||::|:||.||::..:|:|.|||||||||||||||||||:::||..||.|||.||:||:|.|
Zfish    96 PKKGIQFLIENELLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNL 160

  Fly   475 VQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVK 539
            |||||||||||||||||||||||||.|||||||.||.:|.:|||||||||||||||||||||:||
Zfish   161 VQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNPGVFQSTDTCYVLSFAIIMLNTSLHNPNVK 225

  Fly   540 DKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQG 604
            |||:.::||.||||||:|||||..||.:|||||:.||||||:||||||.|||||||:||||.|.|
Zfish   226 DKPSAERFICMNRGINDGGDLPEDLLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLG 290

  Fly   605 GRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFATGGAD-IIK 668
            ||.|:||||||||.|||||||||||||||||||||||:|:||:.|..||:|||||.....| :||
Zfish   291 GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELFIPDNKDQVIK 355

  Fly   669 ACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKKALS 725
            ||||:::|:||||.||.||:||.|.|::::|||.:..:||.:|||::|..|||||.|
Zfish   356 ACKTEADGRVVEGNHTFYRISAPTTEEKEDWIKSIKSAISRDPFYEMLAARKKKASS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	137/179 (77%)
		PH_GRP1-like	592..710	CDD:269954	80/118 (68%)
		PH	596..708	CDD:278594	74/112 (66%)
cyth1b	XP_005169523.1	GPS2_interact	18..90	CDD:292412	15/58 (26%)
		Sec7	81..263	CDD:279680	137/181 (76%)
		PH_GRP1-like	278..397	CDD:269954	80/118 (68%)
		PH	282..395	CDD:278594	74/112 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592607
Domainoid	1	1.000	298	1.000	Domainoid score	I1419
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm25514
orthoMCL	1	0.900	-	-		OOG6_103039
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.750