DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Farp2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001101703.1	Gene:	Farp2 / 316639	RGDID:	1308003	Length:	1060	Species:	Rattus norvegicus

Alignment Length:	787	Identity:	150/787 - (19%)
Similarity:	245/787 - (31%)	Gaps:	281/787 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SNSTFYVNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGDRNETPTMATPKSD 140
            :|::||....::||...     |.::..|.|...|.:..::      :.:.:|:..|:.:...|.
  Rat   403 ANASFYPPPTSLSSPGL-----PSVKDSSSSPVDPQAPHIK------STAAERSSRPSSSEGPST 456

  Fly   141 IKIALKPPP--KPRSPSMAPYTSVATYNITKLAPDSPPPA----------SP----TLSTQTVNC 189
            ....|..||  :|     .|..||          |||.|:          ||    :|||.....
  Rat   457 QSAHLPGPPVLQP-----GPGFSV----------DSPQPSPSSLKSRLSLSPERQASLSTAEQGS 506

  Fly   190 SDVTTKV---TEVQRLPCDEPNTELISKRTEYKHTT----------ITTTTRTLIVSRPVELLLN 241
            |.|.:.|   |...|:...|        ..::|||:          |..|.||.:  :.:|::..
  Rat   507 SPVLSPVLSGTGTARMDNQE--------EQKHKHTSEDEAYFIAKEIVATERTYL--KDLEVITV 561

  Fly   242 ENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPC------------SKNSLPPPPYID 294
            ....::.:.....:...:|              ||...||.            .:.:|...|...
  Rat   562 WFRSVVIKEEAMPAALMTL--------------LFSNIDPIYEFHRGFLHEVEQRLALWEGPSSG 612

  Fly   295 DMRFIDD------------SSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLC------- 340
            |.:.|.|            :|..|...|..:.:.|..|:..:  .....:|.:...:|
  Rat   613 DHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKR--LEAVYKEFELQKVCYLPLNTF 675

  Fly   341 --------ESCRMLLDR----------NY------------INTEQSDNLVILRRPSK--QIKDE 373
                    ...|:||:|          :|            :.||...:|..|....|  :::.:
  Rat   676 LLKPVQRLVHYRLLLNRLCTHYSPEHEDYTDCHEALKAITEVTTELQQSLTRLENLQKLTELQRD 740

  Fly   374 LCEVVSEMEALDVP------EDCKHSNKDKQMSIGRKKFNMDPKKGIE---YLVENRLLRHDPQD 429
            |..|    |.|..|      |.|.|..               .|||::   :.:.:.:|.:..:.
  Rat   741 LVGV----ENLIAPGREFIREGCLHKL---------------TKKGLQQRMFFLFSDMLLYTSKS 786

  Fly   430 VAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFT-----NLILVQALRQFLWSFRLPG 489
            |.       |.::..|..:|..:....||....:...|.||     ..|:|.|      |.||..
  Rat   787 VT-------GASQFRIRGFLPLRGMLVEDSENEWSVPHCFTIYAAQKTIVVAA------STRLEK 838

  Fly   490 EAQKIDRMMETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMN 551
            |....|            ||..|   .:..||..||          |..|.....|.....:|:.
  Rat   839 EKWMQD------------LNAAIQAAKSAGDTPAVL----------LGGPVYTRSPRSSDEVSLE 881

  Fly   552 RGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFF---------------NPDKEGWLW 601
            ...:..|  .||.||.           ..|...|..||..:               .....|:|.
  Rat   882 DSEDGRG--TRGSLEG-----------NSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLL 933

  Fly   602 KQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISV---REIHDRSKPHCFELFATGG 663
            ::......|::.|.:..:.||::::...|..|...:||...||   ||.....|.:.|:|
  Rat   934 RKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKL----- 993

  Fly   664 ADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEW---IKR----------LTQSISH-NPFYD 714
                            :.|..||...|.::...:.|   |||          .||..|| :|..:
  Rat   994 ----------------QFKSHVYFFRAESKYTFERWMEVIKRASSSPGRPPSFTQDCSHLSPGLE 1042

  Fly   715 ILVQRKK 721
            ..|:.|:
  Rat  1043 AEVREKE 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	37/190 (19%)
		PH_GRP1-like	592..710	CDD:269954	29/149 (19%)
		PH	596..708	CDD:278594	27/127 (21%)
Farp2	NP_001101703.1	B41	45..234	CDD:214604
		FERM_C_FARP1-like	221..341	CDD:270014
		FA	333..375	CDD:400882
		RhoGEF	539..718	CDD:238091	27/196 (14%)
		PH1_FARP1-like	747..853	CDD:269928	29/145 (20%)
		PH2_FARP1-like	924..1021	CDD:270055	25/117 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910