DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and CG5937

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster

Alignment Length:	787	Identity:	135/787 - (17%)
Similarity:	239/787 - (30%)	Gaps:	304/787 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HQKRPSISNWFSSLRRQPKNKKCSPGLGGSESVGRKQPLQRSCLDLSTTRVGCDGCVSLEFFQSE 69
            |...|.|.:|...:.:          .|.|..:..|.  .:.|..::|..|       :||.:..
  Fly  1404 HLLVPMIQDWLRYINK----------TGSSWQLVEKN--FKHCCCMTTDLV-------VEFIEKS 1449

  Fly    70 SPESRR---------------SNSTFYVNTQNVSSAVFKDNRQ----PLLERGSG----SDSSPS 111
            .||.||               :::..|...:.|:..:.::.:|    .:.:.|.|    .|||.|
  Fly  1450 VPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSSSS 1514

  Fly   112 SVCVRCSCNSITKSGDRN---ETPTMATPKSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPD 173
            |.......|.....|..:   |:||..:  ....:|||                   .:..:..:
  Fly  1515 SASEEQQKNGGGVGGGGSNLIESPTKIS--GSATLALK-------------------QLLLVLIE 1558

  Fly   174 SPPPASPTLSTQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVEL 238
            ....:...::..:|:|                            .||..::|           .:
  Fly  1559 CAAQSQEAIARISVSC----------------------------LKHVILST-----------GM 1584

  Fly   239 LLNENGEIIARRSPRKSRSNSLG--RMLDVQNEIGTGGLFMEADPCSKNSLPPPPYIDDMRFIDD 301
            |.||:..:||..:..::.:.::.  |.|..        .|.|    ..||           |..|
  Fly  1585 LFNESQWMIACSAIHRACTVTIAPLRQLSF--------AFHE----KSNS-----------FYGD 1626

  Fly   302 SSNSQSESERNSNIHKTNKYTSKNNN---NDSKRESQQSNL----CESCRMLLDRNY------IN 353
            .:|.:..:.|:|::.:..:..:....   :|::||..|:..    ...|::..||:|      :|
  Fly  1627 CANVKVAARRDSSLEELARIYALAQQVFLSDNQREPGQNQAPTPSASQCKLSDDRSYSFLLYPLN 1691

  Fly   354 TEQSDNL--VILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEY 416
            ...:.||  .::|.|.|.:      ||.
  Fly  1692 NGFNSNLDNFVIRIPFKNL------VVG------------------------------------- 1713

  Fly   417 LVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDF-----TNLILVQ 476
            |:.|::|.   |.||..|.........|:...:     |:.....|....||:     :..||::
  Fly  1714 LLANQMLL---QLVAKLLLSRLKCVPQAVSTCI-----FDNYAASAASPSHDYDLDFRSKEILLR 1770

  Fly   477 ALRQFLWSF----RLPG---EAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLH 534
            .::|:|.|.    ..||   ..||:.. :|..|..|.|:         |...:.:.|.::::.|:
  Fly  1771 CVKQYLMSALEFDSRPGLKFLMQKVSN-IEYAANLYKQM---------TSSWMIYYIALVDSHLN 1825

  Fly   535 NPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGW 599
            :..|               .|.|.:....:|||. ..:.|...|                .||.:
  Fly  1826 DIVV---------------YNLGPEDLNFILESC-SRLNTTTVK----------------KKENF 1858

  Fly   600 LWKQGGRYKSWKRRWFILNDN----CLYYFEYTTDKEPRGIIPLENISVREI------------- 647
            :           |..|.|.|.    |..|              |.|.::.||
  Fly  1859 V-----------RYLFCLQDAWNLVCELY--------------LSNSALHEIESGSGKLRQKPPQ 1898

  Fly   648 ---HDRSKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSIS- 708
               |.::||.|..|...|.|::     ||:......|..|........:|::...:..|.....
  Fly  1899 LLHHPQTKPMCISLNGNGDAEM-----TDTGSGSGSGSSTSPSKCVQLQEEENVTMTTLISEFQP 1958

  Fly   709 ---HNPF 712
               .|||
  Fly  1959 KCRSNPF 1965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	35/191 (18%)
		PH_GRP1-like	592..710	CDD:269954	25/141 (18%)
		PH	596..708	CDD:278594	25/131 (19%)
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030