DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and Plekhh2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001178699.2	Gene:	Plekhh2 / 313866	RGDID:	1304935	Length:	1488	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	137/677 - (20%)
Similarity:	230/677 - (33%)	Gaps:	218/677 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 SPPPA-SPTLSTQTVNCSDVTTKVTEVQRLPC---DEPNTELISKRTEYKHTTITTTTRTLIVSR 234
            ||.|: ...||:.|..|.     ::..:..||   .|..:::.|...|:..........  |..:
  Rat   179 SPKPSEGQRLSSLTFGCF-----LSRAKSPPCAVRSEEASKMASSEPEFAEARCVEEME--IAEK 236

  Fly   235 PVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPCSKNS-LPPPPYIDDMRF 298
            |.:..:.||.     ||.||....|.|.    ::...||..|:......::| ||...:..|
  Rat   237 PADNQVQENS-----RSQRKLLETSCGS----EHNRKTGASFVADGGTPEHSGLPVSDWSSD--- 289

  Fly   299 IDDSSNSQSESERNSNI--HKTNK-----------YTSKNNNNDS--KRESQQSNLCESCRMLLD 348
            .||.|..:|:|...|.:  |.:.:           |.:.::::.|  :.|:..:|..:..::...
  Rat   290 DDDGSKGRSKSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSSIFEEETFDANRPQHKKLYSW 354

  Fly   349 RNYINTEQSDNLV-------ILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQM---SIGR 403
            :.....:...||.       :.:|.|.  .|||.:.. :.:.||.......:|....:   ::..
  Rat   355 QQKAPWKAPSNLAKGSSQSEVKQRDSS--SDELNKKF-QSQRLDYSSSSSEANTPSPILTPALTP 416

  Fly   404 KKFNMDPKKGI-----EYLVENRL-------------LRH--DPQDVAHFLYKGEGLNKTAI--- 445
            |..|..|.||.     .:|...:|             .||  .||..:..::   |:|:.||
  Rat   417 KHPNSLPGKGTPLVPPPFLPPPKLRIPNVFSISVALTKRHLSQPQLCSDRMF---GMNRNAISMI 478

  Fly   446 ----------------------------GDYL---------GEKNDFNEDVLKAFVA------LH 467
                                        ||..         .|..:.:|...||..:      ||
  Rat   479 RPLRPQETDLDMVDGDRAEAVDIMDTGCGDLFSYDSQDPPSAEDPENSEATKKASCSKPPTPPLH 543

  Fly   468 DFTNLILVQALRQFLWSFRLPGEAQKIDRMMETF-----------------AQRYCQLNPDIFTN 515
            .|.:           |..|:...|:...|:.|.|                 |..|..|   |:.|
  Rat   544 RFPS-----------WESRIYAVAKSGIRVSEAFNMENANKNAASLLSHSVAGPYMSL---IYKN 594

  Fly   516 TDT-CY-VLSFAIIMLNTS--LHNPSVKDKPTVDQFIS-------------------MNRGINNG 557
            ..| .| .|......::||  |.:.|..|:....:..|                   |.||:::.
  Rat   595 VTTPVYTTLKGKATQISTSPFLDDSSGSDEEDGSRASSRSQSESETRSRSGPNSPRAMKRGVSDS 659

  Fly   558 GDLPRGLLESLYESIRTEPFKIPQ----------DDG-NDLMHTFFNPDKEGWLWKQGGRYKSWK 611
            .:....:....| ||.||..:..|          |:| ::|:      :|.|:|.|..||.|:|:
  Rat   660 SEGDYAIPPDAY-SIDTECSQPEQKLLKTCSTSSDNGKSELL------EKSGYLLKMSGRLKTWR 717

  Fly   612 RRWFILNDNCLYYFEYTTD--KEPRGIIPLENISVREIHDRSKPHCFELFATGGADIIKACKTDS 674
            ||||:|....|.|:...:|  ::|:|.|.|                     :....|::.....:
  Rat   718 RRWFVLKGGELLYYRSPSDVIRKPQGHIEL---------------------SASCSILRGDNKQT 761

  Fly   675 EGKVVEGKHTVYRMSAATEEDQQEWIK 701
            .....| |||.| ::|.:....:||||
  Rat   762 VQLTTE-KHTYY-LTADSPNILEEWIK 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	52/288 (18%)
		PH_GRP1-like	592..710	CDD:269954	31/112 (28%)
		PH	596..708	CDD:278594	31/108 (29%)
Plekhh2	NP_001178699.2	SMC_N	<20..>254	CDD:330553	20/86 (23%)
		PH1_PLEKHH1_PLEKHH2	702..797	CDD:241436	31/108 (29%)
		PH-like	800..>869	CDD:327399
		MyTH4	951..1106	CDD:214535
		B41	1119..1350	CDD:214604
		FERM_C-lobe_PLEKHH1_PLEKHH2	1346..1444	CDD:241360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910