DRSC/TRiP Functional Genomics Resources

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Protein Alignment step and Arfgef1

DIOPT Version :9

Sequence 1:NP_001036375.2 Gene:step / 35425 FlyBaseID:FBgn0086779 Length:727 Species:Drosophila melanogaster
Sequence 2:NP_001263985.1 Gene:Arfgef1 / 312915 RGDID:1560793 Length:1846 Species:Rattus norvegicus


Alignment Length:640 Identity:163/640 - (25%)
Similarity:253/640 - (39%) Gaps:165/640 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 LSTTRVGCDG-CVSLEFFQSESPESRRSNST-----FYVNTQNVSSAV--FKDNRQPLLERGSGS 106
            ||...|.||| |       .|.|:....:..     ..|......:||  ..|.....:|.||.|
  Rat   307 LSKDDVLCDGEC-------EEKPQDIVQSIVEEMVDIIVGDMGEGTAVSASADGNAGAVEDGSDS 364

  Fly   107 DS--------SPSSVC---------VRCSCNSITKSGDRNETPTMATPKSDI------------- 141
            ::        :|.|..         :..|.|...:||: :..|:.....|.|             
  Rat   365 ENVQANGIPGTPISAAYTPSLPDDRLSVSSNDTQESGN-SSGPSPGAKFSHILQKDAFLVFRSLC 428

  Fly   142 KIALKP----PPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDV---------- 192
            |:::||    ||.|:|..:.  :.:.:..:......:   |.|...|..:..:.:          
  Rat   429 KLSMKPLSDGPPDPKSHELR--SKILSLQLLLSILQN---AGPVFRTNEMFINAIKQYLCVALSK 488

  Fly   193 --TTKVTEVQRLPCDEPNTELISKRT-------------------------EYKHTTITTTTRTL 230
              .:.|.||..|......|.|.:.:|                         ::|...|.|.||..
  Rat   489 NGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDHKWMVIQTLTRIC 553

  Fly   231 IVSRP-VELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPCSKNSLPPPPYID 294
            ..::. |::.:|.:.::.|        :|...|:::..::|..|....|.               
  Rat   554 ADAQSVVDIYVNYDCDLNA--------ANIFERLVNDLSKIAQGRGSQEL--------------- 595

  Fly   295 DMRFIDDSSNSQSESERNSNIH------------------KTNKYTSKNNNNDSKRESQQSNLCE 341
                  ..||.|..|.|...:.                  ..|..|:......|::|..:....|
  Rat   596 ------GMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEISEIKHPE 654

  Fly   342 SCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQ-MSIGRKK 405
            :.......|.:.:..|..              :....::|...|.||..:...:.|: :..|...
  Rat   655 TINRYGSLNSLESTSSSG--------------IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDL 705

  Fly   406 FNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFT 470
            ||..||:||:||.|..:|...|:|:|.||::.|.|:.|..|::||:.:.||::|:.|:|..|||:
  Rat   706 FNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQAGEFLGDNDKFNKEVMYAYVDQHDFS 770

  Fly   471 NLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY--CQLNPDIFTNTDTCYVLSFAIIMLNTSL 533
            ....|.|||.||..||||||||||||:||.||.||  |.....:|.:.||.|||:::||||.|.|
  Rat   771 GKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDL 835

  Fly   534 HNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESI--------RTEPFKIP 580
            |:|.||:|.|.:|:|.||||||:..|||...|.::|..|        .|:...||
  Rat   836 HSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIP 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stepNP_001036375.2 Sec7 397..577 CDD:279680 89/190 (47%)
PH_GRP1-like 592..710 CDD:269954
PH 596..708 CDD:278594
Arfgef1NP_001263985.1 DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250 2..224
PLN03076 15..1763 CDD:215560 163/640 (25%)
DCB 29..210 CDD:292830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..248
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..410 13/63 (21%)
Sec7_N 416..570 CDD:289549 24/158 (15%)
HUS, DCB:HUS domain interaction. /evidence=ECO:0000250 554..574 3/27 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..684 8/66 (12%)
Sec7 695..879 CDD:279680 88/183 (48%)
Nuclear localization signal (NLS). /evidence=ECO:0000250 708..712 1/3 (33%)
DUF1981 1217..1297 CDD:286414
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1600
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D815698at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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