DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Arfgef2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_851597.2	Gene:	Arfgef2 / 296380	RGDID:	631430	Length:	1791	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	104/259 - (40%)
Similarity:	145/259 - (55%)	Gaps:	23/259 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 YINTEQSDNLVILRRPSKQIKD-------ELCEVVSEMEALD------VPEDCKHSNKDKQ---- 398
            |:|......|...|.|.:::.|       ..|.|.|....:.      :|:|.:.....||
  Rat   589 YVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEI 653

  Fly   399 MSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAF 463
            :..|.:.||..||:||::|.|..:|....:|:|.||::.|.|:.|.:|::||:...||::|:.|:
  Rat   654 IEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAY 718

  Fly   464 VALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY--CQLNPDIFTNTDTCYVLSFAI 526
            |...||.....|.|||.||..||||||||||||:||.||.||  |.....:|.:.||.|||:::|
  Rat   719 VDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSI 783

  Fly   527 IMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHT 590
            |||.|.||:|.||:|.|.:|:|.||||||:..|||...|.|:||.|  |..||...:..:  ||
  Rat   784 IMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEI--EGKKIAMKETKE--HT 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	89/185 (48%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
Arfgef2	NP_851597.2	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224
		PLN03076	11..1718	CDD:215560	104/259 (40%)
		DCB	28..198	CDD:292830
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..350
		Sec7_N	377..531	CDD:289549
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535
		Sec7	650..834	CDD:279680	87/185 (47%)
		DUF1981	1174..1255	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820