DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment step and Plcg2

DIOPT Version :9

Sequence 1:NP_001036375.2 Gene:step / 35425 FlyBaseID:FBgn0086779 Length:727 Species:Drosophila melanogaster
Sequence 2:NP_058864.1 Gene:Plcg2 / 29337 RGDID:3348 Length:1265 Species:Rattus norvegicus


Alignment Length:472 Identity:86/472 - (18%)
Similarity:156/472 - (33%) Gaps:148/472 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 QPKNKKC-----SPGLGGSESVGRKQPLQRSCLDLSTTRVGCDGCVSLEFFQSESPESRRSNSTF 80
            |.||:|.     .|...|...|           :.:|.||.    ...|:|||      ....|:
  Rat   865 QGKNQKAFVFILEPKKQGDPPV-----------EFATDRVE----ELFEWFQS------IREITW 908

  Fly    81 YVNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITK----SGDRNETPTMATPKSDI 141
            .::|        |:|.....||........|.:.|.|...|.||    :.|..|..:....|:|.
  Rat   909 KIDT--------KENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADS 965

  Fly   142 KIALKPPPKPRSPSMAPYTSVATYN---ITKLAPDSPPPASPTLSTQTVNCSDVTTKVTEVQRLP 203
            .:..||            ..:..||   :|::.|..          |.|:.|:.           
  Rat   966 IVRQKP------------VDLLRYNQKGLTRVYPKG----------QRVDSSNY----------- 997

  Fly   204 CDEP-------------NTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKS 255
              :|             |.:...|..:..|...:...||..|.:| |.:.:|..:.:...|.||.
  Rat   998 --DPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQP-ESMRSEKYDPMPPESQRKI 1059

  Fly   256 RSNSLGRMLDVQN--EIGTGGL--FMEADPC--------------SKNSLPP------------- 289
            ......::|..::  ::|....  |:|.:.|              :.|.|.|             
  Rat  1060 LMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEI 1124

  Fly   290 -PPYIDDMRFI---DDSSNSQSESERNSNIHKT-------NKYTSKNNNNDSKRESQQSNLCESC 343
             .|.:..:||:   :|..     |:.|...|.|       :.:.|....|....:.:.::|...|
  Rat  1125 YDPNLAFLRFLVYEEDMF-----SDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFC 1184

  Fly   344 RMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKD---KQMSIGRKK 405
            .|   |..:.:|:.     |....:|::....|:.:::...|..::.:.:|:|   |:.::...:
  Rat  1185 EM---RPVLESEEE-----LYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQ 1241

  Fly   406 FNMDPKKGIEYLVENRL 422
            ..:..:|....|.|.|:
  Rat  1242 LRLYQEKCNRRLREKRV 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stepNP_001036375.2 Sec7 397..577 CDD:279680 5/26 (19%)
PH_GRP1-like 592..710 CDD:269954
PH 596..708 CDD:278594
Plcg2NP_058864.1 PH_PLC_gamma 22..140 CDD:270168
PH-like 235..>276 CDD:302622
PI-PLCc_gamma 311..>458 CDD:176534
PH-like 475..>510 CDD:302622
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186
SH3_PLCgamma2 773..827 CDD:212902
PHsplit_PLC_gamma <840..910 CDD:270054 15/65 (23%)
PI-PLCc_GDPD_SF <926..1031 CDD:301322 23/139 (17%)
C2_PLC_like 1061..1187 CDD:175974 21/133 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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