DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and CYTH4

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_037517.1	Gene:	CYTH4 / 27128	HGNCID:	9505	Length:	394	Species:	Homo sapiens

Alignment Length:	360	Identity:	228/360 - (63%)
Similarity:	289/360 - (80%)	Gaps:	1/360 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 KQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAH 432
            :::|||:.:|.::::..:..|:.:.:.|:|::.||||||||||.|||:|.:|::||..|.||:|.
Human    34 QKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIAR 98

  Fly   433 FLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRM 497
            ||||||||||||||.||||::..|..||:|||..|:|.||.||||||||||||||||||||||||
Human    99 FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRM 163

  Fly   498 METFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPR 562
            ||.||.|||..||.:|.:|||||||||:|||||||||||:|:|:|..::|:|||||||||.|||.
Human   164 MEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPE 228

  Fly   563 GLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEY 627
            ..|.:|::||::|||.||:||||||.|||||||:||||.|.|||.|:||||||||.||||||||:
Human   229 DQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEF 293

  Fly   628 TTDKEPRGIIPLENISVREIHDRSKPHCFELF-ATGGADIIKACKTDSEGKVVEGKHTVYRMSAA 691
            ||||||||||||||:||:::.|..||.|.||: .:.....|||||||.:|:||||||..||:||.
Human   294 TTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISAT 358

  Fly   692 TEEDQQEWIKRLTQSISHNPFYDILVQRKKKALSK 726
            :.|::.:||:.:..||:..||||::..||||..||
Human   359 SAEERDQWIESIRASITRVPFYDLVSTRKKKIASK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	125/179 (70%)
		PH_GRP1-like	592..710	CDD:269954	74/118 (63%)
		PH	596..708	CDD:278594	69/112 (62%)
CYTH4	NP_037517.1	Sec7	61..243	CDD:279680	126/181 (70%)
		PH_GRP1-like	258..376	CDD:269954	74/117 (63%)
		PH	262..374	CDD:278594	68/111 (61%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275		4/6 (67%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..394		6/8 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3769
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm41895
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.920