DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and sec71

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_594954.1	Gene:	sec71 / 2543610	PomBaseID:	SPAC4D7.01c	Length:	1811	Species:	Schizosaccharomyces pombe

Alignment Length:	511	Identity:	144/511 - (28%)
Similarity:	217/511 - (42%)	Gaps:	134/511 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNC-------------- 189
            |||.:.::.|....:|.:   .:|..|....||.:   ..|..|....::|
pombe   426 SDINVKIRSPTSTPTPLI---DAVKQYICLALAKN---VVSHVLPVFEISCEIFWLILSELKNFF 484

  Fly   190 -SDVTTKVTEV-------------QRL--------PCDEPNT--------ELISKRTE--YKHTT 222
             |::....||:             |::        .|:||.|        :.||..||  |:...
pombe   485 KSELEVFFTEIFFPILEMRTSSNQQKIVLLNIFHRMCEEPQTLIELYLNYDCISGNTENIYERAI 549

  Fly   223 ITTT-----------------TRTLIVSRP--VELLLNENGEIIARRSPRKSRSNSLGRMLDVQN 268
            :|.:                 ...|::.:|  |...||:..::         .|:::|..:...|
pombe   550 VTLSRIASQSTSDPPPSFVFRDDQLVIDKPGFVYHTLNDIPQL---------NSSTIGSYVHSHN 605

  Fly   269 EIGTGGLFMEADPCSKNSLPPPPYIDDMRFIDD-----SSNSQSESERNSNIHKTNKYTSKNNNN 328
                                 |||.|....:..     |:.|...:..|.....|.:.|:|::..
pombe   606 ---------------------PPYFDYQIRLKSYRCLISTLSSLFTWCNQTFAPTVEITAKDDET 649

  Fly   329 D--SKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVP---E 388
            :  ||.|..|.:..|.     ....||:...|||               |...:..|.|.|   |
pombe   650 ESTSKGEEPQKSKSEP-----PSAGINSTSMDNL---------------ESSGQALATDDPSQFE 694

  Fly   389 DCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLL-RHDPQDVAHFLYKGEGLNKTAIGDYLGEK 452
            :.||..|..|.:|  :|||..||:||:.|:.:..: ...|.|:|.||...|||:|..:|:||||.
pombe   695 NLKHRKKQLQEAI--QKFNYKPKEGIKILLSSHFIASKTPTDIAKFLISTEGLDKAVLGEYLGEG 757

  Fly   453 NDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTD 517
            ||.|..::.:||....|.::..|.|||.||..||||||||||||.|..||::|...|..:|.|.|
pombe   758 NDENIAIMHSFVDHMSFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKYIDDNLGVFKNAD 822

  Fly   518 TCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIR 573
            |.|:|:::||||||.||:|.||::.|...||..|||:::|.:|....|..:||.|:
pombe   823 TAYILAYSIIMLNTDLHSPQVKNRMTCQDFIKNNRGVDDGANLSDSFLTEVYEEIQ 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	82/178 (46%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
sec71	NP_594954.1	DCB	110..304	CDD:292830
		Sec7_N	372..536	CDD:289549	20/115 (17%)
		COG5307	380..1562	CDD:227623	144/511 (28%)
		Sec7	699..882	CDD:279680	83/182 (46%)
		DUF1981	1248..1331	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810