DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and sec72

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_594555.1	Gene:	sec72 / 2542107	PomBaseID:	SPAC30.01c	Length:	1822	Species:	Schizosaccharomyces pombe

Alignment Length:	408	Identity:	124/408 - (30%)
Similarity:	196/408 - (48%)	Gaps:	68/408 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EYKHTTITTTTRTLIVSRP--------VELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTG 273
            :.|:|:......||::.:.        |||.:|.:.:       |.|.:|...::|...:::.|.
pombe   515 DLKNTSYNQKLHTLLIIQRICLNPRALVELYINYDCD-------RSSTTNVFEQLLFSISKVTTN 572

  Fly   274 GLFMEADPCSKNSLPPPPYIDDMRFIDDSSNSQSESERNSN-IHKTNKYTSKN--------NNND 329
            |             |.....:|   |::...|...|||:|. ...||..:.|:        ::..
pombe   573 G-------------PSETISED---IEEILPSLESSERSSTPFLNTNSASLKSEVVQLTTFSDFQ 621

  Fly   330 SKRESQQ---------SNLCESCRMLLDRNYINTEQ------------SDNLVILRRP---SKQI 370
            .|.::.|         ||..|| .:.|.|..::|::            ||..|  ..|   .||.
pombe   622 LKLKTLQCVLDILQSLSNWAES-GLYLSRRGVSTDEQGFVGDYDALSRSDTPV--TNPYYNGKQS 683

  Fly   371 KDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLR-HDPQDVAHFL 434
            .:......|.:...|..:...:..:.|.:.....|||..|.:|::.|.||..:. :||:.:|.||
pombe   684 FEANSHSSSSIALADPSQFESNKQRKKLLRTCINKFNYKPTRGLKMLSENEYVDINDPKAIAEFL 748

  Fly   435 YKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMME 499
            ::.:|::||.:||||||.::.:..|:..|:....|.||..|.|||:.|..||||||||||||:|.
pombe   749 FRADGIDKTTLGDYLGEGDEKSISVMHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIML 813

  Fly   500 TFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGL 564
            .|::||.:.||..|.|.||.|:|:::||:|||.||:|.:|:|.|.:.||..|||||:|.||....
pombe   814 KFSERYMKENPSAFANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGADLDEDY 878

  Fly   565 LESLYESIRTEPFKIPQD 582
            |..:|:.|......:..|
pombe   879 LGFVYDDILKNEIAMKDD 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	81/180 (45%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
sec72	NP_594555.1	Sec7_N	385..552	CDD:289549	8/43 (19%)
		COG5307	393..1561	CDD:227623	124/408 (30%)
		Sec7	708..891	CDD:279680	81/182 (45%)
		DUF1981	1249..1329	CDD:286414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810