DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and sec74

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_594894.2	Gene:	sec74 / 2542073	PomBaseID:	SPAC26F1.01	Length:	928	Species:	Schizosaccharomyces pombe

Alignment Length:	470	Identity:	105/470 - (22%)
Similarity:	177/470 - (37%)	Gaps:	101/470 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTMATPKSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDVTTKV 196
            |:....||.::.||:  .|.|.....|..::.:        |:|..:|......:....|.||.:
pombe    30 PSRRKGKSALRSALE--KKNRKSKSKPKVTITS--------DTPKVSSQHSPVSSAYTGDSTTDL 84

  Fly   197 TEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKSRSNSLG 261
                    |..:....|::...|            ||..::|.:.:..     ||.:.|.|....
pombe    85 --------DSKSGHSSSQKLSNK------------VSSALKLTIPKRW-----RSSKSSSSQCSS 124

  Fly   262 RMLDVQNEIGTG---GLFM---EADPCSKNSLPPPPYIDDMRFIDDSSNSQSESERNS------- 313
            ..|...:..|.|   .|.:   ::.|.|::|:    ::.:...|..|:.|.::|:.:.
pombe   125 PFLPTSSSNGHGDDASLNLPDKKSRPSSQSSI----FLSNWSTIFSSNASPTDSQLSPTHTSTIA 185

  Fly   314 -------NIHKTNKYTSKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIK 371
                   :|..:..|......:.|:.....|.       .|.|:......|.|.......|.|
pombe   186 ELAASTLSIFPSGSYAGSTFGSPSRSSIDSST-------YLPRSKSVNSLSSNFSARTPASNQ-- 241

  Fly   372 DELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKF---NMDPKKGIEYLVENRLLRHDPQDVAHF 433
                  .|..|......:|.|    |..|:....|   ::|....:|.::|........|.....
pombe   242 ------SSVSEDFGAAPNCDH----KHNSVTLSDFALPDIDQHDTVETILEKVEFTIPKQFTPAI 296

  Fly   434 LYKG-EGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRM 497
            |.:| ..|.|..:..||...|               |..:.|..|||:||..:.||.|.|:|||:
pombe   297 LSQGTSSLLKLCLRKYLSVVN---------------FKCISLDMALRKFLAVYVLPNETQQIDRV 346

  Fly   498 METFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPR 562
            :.||:.:|...|||::.::|.||:|:|::::|:|...|...:.|.|..:|||   ..|....||.
pombe   347 LSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKMTRAEFIS---NTNLPTILPE 408

  Fly   563 GLLESLYESIRTEPF 577
             :||..|::|...||
pombe   409 -ILECFYDNITYTPF 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	54/183 (30%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
sec74	NP_594894.2	Sec7	<308..422	CDD:279680	43/132 (33%)
		PH	549..676	CDD:278594
		PH	549..676	CDD:214574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000