DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and SPBC211.03c

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_596613.1	Gene:	SPBC211.03c / 2540746	PomBaseID:	SPBC211.03c	Length:	1462	Species:	Schizosaccharomyces pombe

Alignment Length:	538	Identity:	137/538 - (25%)
Similarity:	229/538 - (42%)	Gaps:	100/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 HTTITTTT----RTLIVSRPVELLLNENGEI--------IARRSPR-KSRSNSLGRM---LDVQN 268
            ||.:.|.:    .||:.:.|..|.|.:...|        |...:|| ::...||.::   ||:..
pombe   353 HTALLTNSLLVMTTLLQAMPGSLKLQQELFISYLISCLHIPSTTPRERNVETSLHKVVSSLDLSE 417

  Fly   269 EI----GTGGLFMEADPCSKNSLPPPPYIDDM-------------RFIDDSSNSQSESERNSNIH 316
            ||    .|...|.|....:.::...||.:.::             ..||...|...:.:.:....
pombe   418 EISPDRATPTSFTERKRFAFDTRNRPPEVRELIVECLGSLSRIPYFLIDLYVNYDCDPQMSDLAI 482

  Fly   317 KTNKYTSKNNNNDSKRESQQSNLCESCRMLLDR--NYINTEQSDNLVILRRPSKQIKDELCEVVS 379
            ...|..::|...||.|.| .:|:...|   ||.  |:|.............|:...||::.:.:.
pombe   483 DLLKVLTRNCLVDSARYS-TANVPPLC---LDALLNFIYYFHEHLQPCYNDPNNTFKDDVAKTLI 543

  Fly   380 EMEALDVPEDCKHSNKDKQMSI-GRKKFNMDPKKGIEYLVENRLLRH--DPQDVAHFLYKGEGLN 441
            |            |.|.|.:.| |.:.||..|..||.:|.::.:::.  :|..:..|.:....|:
pombe   544 E------------SKKRKAIIIEGAELFNESPSDGIAFLTQHSIIKQSDNPTCIVEFFHSTNRLS 596

  Fly   442 KTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYC 506
            |..:|::|.:.:  |..:|.||::..||....:.:|||..|.|||||||:|.|:|::|||:..|.
pombe   597 KRVLGEFLTKGS--NSHILNAFISAFDFKGKRIDEALRLLLQSFRLPGESQLIERVLETFSHYYM 659

  Fly   507 QLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKD--KPTVDQFISMNRGINNGGDLPRGLLESLY 569
            ..|||..::.|..:|||::||||||..|||::|.  :.|:|.|....||:|:|.|..|..|..:|
pombe   660 SANPDSMSSKDAAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCRNVRGVNDGQDFDRNFLSEIY 724

  Fly   570 ESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPR 634
            ::|:.....:.::...:|...:        :|.:                  |......|:...|
pombe   725 KAIKENEIIVAEEHDTELSFLY--------IWSK------------------LQQSVKITEPFKR 763

  Fly   635 GIIPLENISVREIHDRSKPHCFELFATGGADIIKACKTDSEG----KVVEGKHTVYRMSAATE-- 693
                    |...:||  |....|::.:..|.:|....|.:|.    :||.|......::||.|
pombe   764 --------SSSNVHD--KIVFLEVWKSIMAALIYVFSTATEDTVFYRVVNGIQQATEVAAAYELN 818

  Fly   694 EDQQEWIKRLTQSISHNP 711
            |.....|:|..|..:.:|
pombe   819 EPVDYAIERFCQFTALDP 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	68/184 (37%)
		PH_GRP1-like	592..710	CDD:269954	23/123 (19%)
		PH	596..708	CDD:278594	23/117 (20%)
SPBC211.03c	NP_596613.1	Sec7_N	287..475	CDD:289549	26/121 (21%)
		COG5307	289..1303	CDD:227623	137/538 (25%)
		Sec7	548..732	CDD:279680	68/185 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910