DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Arhgap22

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_006519017.1	Gene:	Arhgap22 / 239027	MGIID:	2443418	Length:	738	Species:	Mus musculus

Alignment Length:	180	Identity:	46/180 - (25%)
Similarity:	81/180 - (45%)	Gaps:	30/180 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 ISMNRGI-NNGG------------DLPRGLLESLYESIRTEPFKIPQDD---GNDLMHTFFNPD- 595
            :.:.||| .|.|            ..|:..|.|:....|::...:.:..   |..|:.....|.
Mouse     1 MKIRRGIQENSGRAAAPHNLKGIFQHPQNSLASVVTPARSKSLVMGEQSRSPGRPLVPHKLGPVL 65

  Fly   596 KEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVRE-IHDRSKP--HCFE 657
            |.|||.||....|:|::|||:|..:.|:|::...:.:|:|.|.|:...|.| :.|...|  |.||
Mouse    66 KAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPEDPGKHLFE 130

  Fly   658 LFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSI 707
            : ..|||         :|.:.|........:.|:::.|.::|::.:.:.|
Mouse   131 I-TPGGA---------TEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	9/41 (22%)
		PH_GRP1-like	592..710	CDD:269954	35/120 (29%)
		PH	596..708	CDD:278594	34/115 (30%)
Arhgap22	XP_006519017.1	PH-like	62..177	CDD:388408	35/119 (29%)
		RhoGAP_ARHGAP22_24_25	193..391	CDD:239855
		Macoilin	<529..>719	CDD:370635
		HCR	<638..719	CDD:284517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910