DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and PSD4

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_036587.2	Gene:	PSD4 / 23550	HGNCID:	19096	Length:	1056	Species:	Homo sapiens

Alignment Length:	747	Identity:	161/747 - (21%)
Similarity:	266/747 - (35%)	Gaps:	256/747 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGLGGSES--VGRKQPLQRSCLDLSTTRVGCDGCVSLEF---------FQSESPESRRSNSTFY- 81
            ||.|.||.  :| ..|....|:|.:.|..  .|||..:.         :.|.|||..:....|:
Human   346 PGHGESEGDRLG-PAPSAAPCVDEALTWE--SGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWP 407

  Fly    82 ---VNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGDRNETPTMATPKSDIKI 143
               :|:|:      :|.|    |.|...:|.|.:: ..|...|...|      |..::|:|:.:
Human   408 QVTLNSQD------RDER----EGGHPQESLPCTL-APCPWRSPASS------PEPSSPESESR- 454

  Fly   144 ALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDVTTKVTEVQRLPCDEPN 208
              .|.|:|                   :|.|....||.|...:   |.:..|.|      .|...
Human   455 --GPGPRP-------------------SPASSQEGSPQLQHHS---SGILPKWT------LDASQ 489

  Fly   209 TELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTG 273
            :.|:....|                :|..|...|.||     :|:...        :|::| ||
Human   490 SSLLETDGE----------------QPSSLKKKEAGE-----APKPGE--------EVKSE-GT- 523

  Fly   274 GLFMEADPCSKNSLPPPPYIDDMRFIDDSSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSN 338
                 |.|.....:.|                        :||.|:              ::..|
Human   524 -----ARPAETGDVQP------------------------DIHLTS--------------AEHEN 545

  Fly   339 LCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGR 403
            |    |..::.:::             |.           |.|.....||:.:......:::.|
Human   546 L----RTPMNSSWL-------------PG-----------SPMPQAQSPEEGQRPPAGDKLANG- 581

  Fly   404 KKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHD 468
                          |.|..:   ..::|..||:.||..|:.:..||.:.|||:..|.:.:::...
Human   582 --------------VRNNKV---AWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQ 629

  Fly   469 FTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSL 533
            |....|.:|||.||.:..|.||.|:.:|::..|::|:...||.||.:.|:.:.|:.||::|||.|
Human   630 FGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDL 694

  Fly   534 HNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNP---- 594
            |..::....:..:||:...|:.:||:.|:.||::||.|||:|..:...|:.:........|
Human   695 HGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPA 759

  Fly   595 ------------DKEGWLWKQG-----------GRYKSW-KRRW----FILNDNCLYYFEYTTD- 630
                        |.....:|||           |:...| ||.|    .:|....||:.:...|
Human   760 GKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDH 824

  Fly   631 ------------KEPRGIIPLENISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVEGKH 683
                        .||.|:  ..:::....|...|||.|:|..   ||                 .
Human   825 CLEGESLVGQMVDEPVGV--HHSLATPATHYTKKPHVFQLRT---AD-----------------W 867

  Fly   684 TVYRMSAATEEDQQEWIKRLT-QSISHN--PF 712
            .:|...|.|.::...||.|:. .:.:|:  ||
Human   868 RLYLFQAPTAKEMSSWIARINLAAATHSAPPF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	56/179 (31%)
		PH_GRP1-like	592..710	CDD:269954	31/163 (19%)
		PH	596..708	CDD:278594	29/141 (21%)
PSD4	NP_036587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..239
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..362		7/16 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..533		45/228 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..581		7/62 (11%)
		Sec7	570..738	CDD:238100	56/185 (30%)
		PH_EFA6	772..900	CDD:270107	33/150 (22%)
		PH	794..892	CDD:278594	25/119 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810