DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and DOCK9

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_006719985.1	Gene:	DOCK9 / 23348	HGNCID:	14132	Length:	2141	Species:	Homo sapiens

Alignment Length:	428	Identity:	75/428 - (17%)
Similarity:	130/428 - (30%)	Gaps:	160/428 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 HKTNKYTSKNNNNDSKRESQQSN-----LCESCRMLLDRNYINTEQSDNLVILRRPSK-----QI 370
            |.|.|:      .|:...|:.:|     ..:.|...:||.:: .:|.:|.:....|..     :.
Human  1018 HITQKF------RDNPEASKNANHSLAVFIKRCFTFMDRGFV-FKQINNYISCFAPGDPKTLFEY 1075

  Fly   371 KDELCEVVSEMEALDVPEDCKHSN---KDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAH 432
            |.|...||           |.|.:   .:..|..|:.:........::|.:.:...|:      |
Human  1076 KFEFLRVV-----------CNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRN------H 1123

  Fly   433 FLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRM 497
            ||.   ||....:|..|.|   |.|            ..||.:..|:..|              :
Human  1124 FLV---GLLLREVGTALQE---FRE------------VRLIAISVLKNLL--------------I 1156

  Fly   498 METFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHN------------PSVKDK----PTVDQ 546
            ..:|..||...:..  ....|.|:..|.:::.|....|            .:|||:    |.|:.
Human  1157 KHSFDDRYASRSHQ--ARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNP 1219

  Fly   547 FISMNRGINNGGDLPRGLLESL-------------YESIRTEPFK---IPQDDGNDLMHTFFNPD 595
            .::..:|......|.:.||.::             ..|:|....:   |..|.||.|...  |.:
Human  1220 LVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPER--NSE 1282

  Fly   596 KEGWLWK-------------------------------------QGGRYKSWKRR-------WFI 616
            |...|.|                                     ....:..|.:.       :|.
Human  1283 KSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFT 1347

  Fly   617 LNDNCLYYFEYT----TDKEPRGIIPLENISVREIHDR 650
            :::.||:.|:|.    ..:...|:.|:       :|||
Human  1348 ISEVCLHQFQYMGKRYIARNQEGLGPI-------VHDR 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	37/208 (18%)
		PH_GRP1-like	592..710	CDD:269954	15/107 (14%)
		PH	596..708	CDD:278594	14/103 (14%)
DOCK9	XP_006719985.1	DUF3398	74..165	CDD:288711
		PH_DOCK-D	181..304	CDD:270087
		PH	186..291	CDD:278594
		C2_Dock-D	650..839	CDD:176079
		DHR2_DOCK9	1646..2097	CDD:212571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910