DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and Iqsec1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_006506046.1	Gene:	Iqsec1 / 232227	MGIID:	1196356	Length:	1203	Species:	Mus musculus

Alignment Length:	674	Identity:	174/674 - (25%)
Similarity:	276/674 - (40%)	Gaps:	135/674 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRPSISNWFSSLRRQPKNKKCSPGLGGSESVGRKQPLQRSCLDLSTTRVG-------CDGCVSLE 64
            :||.:.:..|.||:|.:.:........|||......||...:::...:.|       ....:...
Mouse   169 RRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTA 233

  Fly    65 FFQ--------------SESPESRR---SNSTF---YVNTQNVSSAVFKDNRQPLLERGSGSDSS 109
            |.|              ||:..|||   ||...   :...:.|.|:.|:..:..:.     :|.|
Mouse   234 FRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVT-----NDGS 293

  Fly   110 PSSVCVRCSCNSITKSGDRNETPT--MATPKSDIKIALKPPPKPRSPSM-------------APY 159
            .....|...|..::....::..|:  .|...::::.|.....|..:.|:             .|.
Mouse   294 QLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPA 358

  Fly   160 TSVATYNITKLAPDSPPPASPTLSTQTVNCSDVTTKVTEVQRLP-------CDEPNTELISKR-- 215
            :..|....|:..|.........|...|.:.||||..:.|.:..|       .|.|::.....|
Mouse   359 SDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLR 423

  Fly   216 -------------TEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSP---------RKSRSN 258
                         .|.|..|.|:...|..:.||...|..|:..::....|         |..||
Mouse   424 SGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRS- 487

  Fly   259 SLGRMLDVQNEIG----------TGGLFMEADPCSKNSLP---------PPPYIDDMRFIDDSSN 304
            ||.|....:..:|          .||        ....||         ||..::....|:.|:|
Mouse   488 SLKRQSAYERSLGGQQGSPKHGPHGG--------PPKGLPREEPELRPRPPRPLESHLAINGSAN 544

  Fly   305 SQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQ 369
            .||:||.:.:....:...|.:|:||:...|.:|:..:|.|          ||:        .|||
Mouse   545 RQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLR----------EQT--------LSKQ 591

  Fly   370 IKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFL 434
            ...:     ....:.|.|.......:.:...||...||..|:|||:||:|...:...|..|||||
Mouse   592 TYHK-----ETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFL 651

  Fly   435 YKGEGLNKTAIGDYLGEK-NDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMM 498
            .:.:||::..||::||.: ..||.|||...|...||:.:.|.:|||:|....|:.|||||::|::
Mouse   652 LQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLI 716

  Fly   499 ETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHNPSVKD--KPTVDQFISMNRGINNGG 558
            |.|:||||..||.:   |.|.||.::|:||||:|||.:::|:||.  |..::.|:...||:::|.
Mouse   717 EAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGE 781

  Fly   559 DLPRGLLESLYESIRTEPFKIPQD 582
            |:||..|..:||.||....|..:|
Mouse   782 DIPRETLIGIYERIRKRELKTNED 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	79/185 (43%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
Iqsec1	XP_006506046.1	Sec7	612..800	CDD:366596	79/187 (42%)
Iqsec1	XP_006506046.1	IQ_SEC7_PH	832..962	CDD:374551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910