Protein Alignment step and IQSEC2

DIOPT Version :9

• Sequence 1: NP_001036375.2
• Gene: step / 35425
• FlyBaseID: FBgn0086779
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: XP_006724642.1
• Gene: IQSEC2 / 23096
• HGNCID: 29059
• Length: 1520
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 158/635 - (24%)
• Similarity: 239/635 - (37%)
• Gaps: 198/635 - (31%)

  Fly    66 FQSESPESRRSNSTFYVNTQNVSSAVFKDNRQPLLER--------GSGSDSSPSSVC-------- 114
            |..|..|..::.:.|.....::........|...|||        |.|.|...|||.
Human   424 FSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSND 488

  Fly   115 -----------VRCSCNSITK------SGDRNETP----------------TMATPKSDIKIALK 146
                       |:....||.:      ||..:|.|                :.||..||:.:.|.
Human   489 ITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLD 553

  Fly   147 PPPKPRSPSMAPYTSVATYNITKL-APDSPPPASPTLSTQT----------------VNCSDVTT 194
            .....:||...|.|........:. ||...||..|.:.:.|                :.|.|...
Human   554 DTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRL 618

  Fly   195 KVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKSRSNS 259
            :...:..|..:.|:...:.                                 ::.||.|.|
Human   619 RAAHLPLLTIEPPSDSSVD---------------------------------LSDRSDRGS---- 646

  Fly   260 LGRMLDVQNEIGTGGLFMEADPCSKNS-------------------------------LPPPPY- 292
                  |..:     |..|||.||.:.                               |||.|.
Human   647 ------VHRQ-----LVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNS 700

  Fly   293 ------IDDMRFI-------DDSSNSQSES-ERNSNIHKTNKYTSKNNNNDSKRESQQSNLCESC 343
                  :...|.:       ::|....:|| |.:||.::|...:|.:::.||.||...:.||:..
Human   701 GTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQT 765

  Fly   344 RMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNM 408
            .....|:..::...:|.|:.||                                ...||...||.
Human   766 YQRETRHSWDSPAFNNDVVQRR--------------------------------HYRIGLNLFNK 798

  Fly   409 DPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEK-NDFNEDVLKAFVALHDFTNL 472
            .|:|||:||:|...|...|..||||:.:.:||::..||::||.: ..||.|||...|...||:::
Human   799 KPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSM 863

  Fly   473 ILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLH 534
            .|..|||:|....|:.|||||::|::|.|:||||..||.:   |.|.||.::|:||||:|||.::
Human   864 DLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMY 928

  Fly   535 NPSVK--DKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQD 582
            :||||  .|..:|.||...||::||.|:||.||..:|:.|:....:...|
Human   929 SPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDD 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	82/185 (44%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
IQSEC2	XP_006724642.1	ATG16	<23..>64	CDD:312208
		Sec7	785..973	CDD:307500	84/219 (38%)
		IQ_SEC7_PH	996..1125	CDD:318620

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910