DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and She

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_766118.3	Gene:	She / 214547	MGIID:	1099462	Length:	492	Species:	Mus musculus

Alignment Length:	474	Identity:	90/474 - (18%)
Similarity:	147/474 - (31%)	Gaps:	153/474 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SNWFSS--LRRQPKNKKCSPGLGG------SESVGRKQPLQRSCLDLSTTRVGCDGCVSLEFFQS 68
            :.||..  |..:..:::..||..|      ||:.|                            .:
Mouse    34 AKWFKEFPLTLKTASERARPGGAGGKPRKNSETGG----------------------------AA 70

  Fly    69 ESPESRRSNSTFYVNTQNVSSAVFKDNR------QPLLERGSGSDSSPSSVCVRCSCNSITKSGD 127
            .:|...|.||...:.....||...||:|      |.|::..:|.....|.|         |.:..
Mouse    71 PTPGKGRKNSAAELGASKASSGPPKDSRLSRDSLQGLIQAAAGKGRKNSRV---------TATAT 126

  Fly   128 RNETPTMATPKSD-----IKIALKPPPKPRSPSMAPY----TSVATYNITKLAPDSPPPASPTLS 183
            ..|....|..||.     |...:|...:.::...| |    ::.::.:.:..|..||....|.|.
Mouse   127 EEEPHRGAVTKSAGCSTYISRLIKVDTQEKNGKSA-YPGGGSTSSSSSSSSSASSSPSSLGPELD 190

  Fly   184 TQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEI-- 246
            ...:.....|..:.|....|.|       :|||:.:              |..|.:...:|.:
Mouse   191 KAKIMRQQDTVIILEDYADPYD-------AKRTKGQ--------------RDAERVGENDGYMEP 234

  Fly   247 ---------IARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADP---CSKNSLPPPPYIDDMRFI 299
                     |.||..:.....:| ::||..:|.|. .:.:||..   .||:.|..||.:.|..:
Mouse   235 YDAQQMITEIRRRGSKDPLVKAL-QLLDGPSEPGE-TVKVEATAKRRSSKDLLGKPPQLYDTPY- 296

  Fly   300 DDSSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNLCESCRMLLDRNY-INTEQSDNLVIL 363
            :.|...|..:|     .||....|:....|.:..::.....|..|..:.|.. :..|.||
Mouse   297 EPSEGGQRVAE-----VKTRPADSRLPEEDDRPAAEYEQPWEWKREQIARALSVQFEGSD----- 351

  Fly   364 RRP------------SKQIKDELCEVVSEMEALDVPEDCKHSNKDK---------------QMSI 401
             ||            .|.:|..|.:               |.:.:|               .:|.
Mouse   352 -RPPGREDAGRPHHWQKTLKPTLSD---------------HGDGEKVDPGLALEKQPWYHGSISR 400

  Fly   402 GRKKFNMDPKKGIEYLVEN 420
            ...:..:.|.|...|||.|
Mouse   401 AEAESRLQPCKEAAYLVRN 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	8/39 (21%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
She	NP_766118.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..193		34/184 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..236		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..332		19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..384		10/57 (18%)
		SH2_SHE	391..488	CDD:198254	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910