DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and max-1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001367137.1	Gene:	max-1 / 179794	WormBaseID:	WBGene00003143	Length:	1099	Species:	Caenorhabditis elegans

Alignment Length:	659	Identity:	125/659 - (18%)
Similarity:	218/659 - (33%)	Gaps:	226/659 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 LSTQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVELLLNENGEI 246
            |..|.:.|:      |::|.|......:..|....|...    :.|.||.|.|......:::| :
Worm    42 LRAQNLRCT------TQLQMLRSFTEKSRKIKAEMEMSR----SITGTLPVLRDENRTSDDSG-L 95

  Fly   247 IARRSPRKSRSNSLGRMLD-VQNE--------IGTGGLFMEADPCSKNSLPPP------------ 290
            .:..:.||..|.|:..... ||.:        ...|....|:.||...:.|.|
Worm    96 TSDDADRKQMSVSISECTPRVQRKAARTMLKNTSQGSSTSESSPCEDEAKPMPLPRRIHPTATER 160

  Fly   291 ----PYIDDMRF-IDDSSNSQSESE-RNS--------NIHK---------------TNKYTSKN- 325
                .|.:|..: |::||..:.|.: ||.        |:|:               .::.|.|.
Worm   161 DSLNSYAEDYEYDIEESSFERHEEQVRNENEKYVDYVNLHEFVAIKDDKVVYSEIVKHRSTEKEY 225

  Fly   326 -----NNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALD 385
                 ::...:.|::.....|.|..::|       .:|:......||          ||.....|
Worm   226 LPALPSHQPRQWENRLIQAAEKCLSVID-------GADSEGTSTGPS----------VSPYHVSD 273

  Fly   386 VPEDCKHSNKDKQMSIGRKKF-----NMDPK--------KGIEYLVENRLLRHD---PQDVAHFL 434
            |   .:.|:.::..|.|.:|.     |..|:        .|..|.:.:..|..|   |.|.:...
Worm   274 V---SRISSNNRTESPGSRKSSKLSRNSSPRVPSHHSYEDGAAYAIRDLCLGSDYYLPPDASSRC 335

  Fly   435 YKGEGLNKTAI---------GDYLGEKNDFNEDVLK-----------AFVALHD----------- 468
            ..|...::|::         ..|..:..|.....||           :|...|:
Worm   336 SGGTPTSRTSLIPSRETMEKSGYWTQLTDSRIKSLKRRYVVFKNGQISFYRKHNNRDEEPASKIS 400

  Fly   469 FTNLILVQALRQ--FLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNT 531
            .:::..|..|.|  ..::|:|.....|::.|.|  ::|         |..|...:||.||  ..|
Worm   401 ISDIRSVTKLEQQGAAYAFQLITSTDKMNFMTE--SER---------TTHDWVTILSAAI--KAT 452

  Fly   532 SLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDK 596
            :|...:.:..| :|..||
Worm   453 TLREMASRVTP-IDASIS----------------------------------------------- 469

  Fly   597 EGWLWKQGGRYKSW--KRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELF 659
             |||    .|.|..  |:.:..|.:..|.:|:.:.|..|.|.:.|:...:.|.|:.::.:
Worm   470 -GWL----TRVKCGLSKKVFAALVNQKLMFFKNSNDLVPNGFLCLQGAQISEKHNGTEEY----- 524

  Fly   660 ATGGAD-IIKACK--------TDSEGKVVEGKHTVYRMSAATEEDQQEWIKRL-----TQSISHN 710
             :|.:| .::..|        .||....:..:..|| :...|.||:::|:..|     |.::...
Worm   525 -SGSSDEQLETTKEHPNQRKNNDSLCVQIANEDPVY-LILRTSEDKEKWLYYLKSASGTAALCGT 587

  Fly   711 PFYDILVQR 719
            || :|||||
Worm   588 PF-EILVQR 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	40/228 (18%)
		PH_GRP1-like	592..710	CDD:269954	28/133 (21%)
		PH	596..708	CDD:278594	28/127 (22%)
max-1	NP_001367137.1	PH	353..450	CDD:214574	21/109 (19%)
		PH	468..579	CDD:214574	29/169 (17%)
		MyTH4	662..766	CDD:395633
		B41	781..996	CDD:214604
		PH-like	992..1088	CDD:418428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910