DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and grp-1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_498764.1	Gene:	grp-1 / 176140	WormBaseID:	WBGene00001743	Length:	393	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	151/409 - (36%)
Similarity:	244/409 - (59%)	Gaps:	38/409 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 SKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPED----- 389
            |.|.|:::.|.|:.:|.|.:             :|:...|:.||:..:.:|:..:|...|
Worm     2 SSRYSERNGLSETEKMTLPK-------------VRKRKAQLVDEIEALKNEVREVDEELDQVYYT 53

  Fly   390 -CKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKN 453
             .|.....|.:..||||||.||.|.:::|....::..|||.:|.::..||||:|:|||:.||:..
Worm    54 HPKSKEYHKIVVNGRKKFNQDPWKALDWLASRNVVAKDPQALALWMKAGEGLSKSAIGEILGDNR 118

  Fly   454 DFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDT 518
            .|..:.|..|...|...::.:|.||||:|:|||||||:|||:|::|.||:.|...||. :.|.|.
Worm   119 PFALETLDRFTKEHKLHDVPIVPALRQYLFSFRLPGESQKINRILEKFAEVYANQNPS-YGNADQ 182

  Fly   519 CYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDD 583
            .:.::::.||:||.||||:|||||:::::|.||..:...|.:....|..:|||:....||||.:.
Worm   183 AHTVAYSCIMVNTLLHNPNVKDKPSLEKYIEMNEQLLEKGAITIEQLTEVYESVSVTQFKIPDEV 247

  Fly   584 G-------NDLMHTFFNPDKEGWLWKQGGR-----YKSWKRRWFILNDNCLYYFEYTTDKEPRGI 636
            .       ||::   .:.::||||:||...     ..|||:|||:|::||||||:..|||||:||
Worm   248 STSGKGTVNDIL---LHAEREGWLFKQSSNPLFSGALSWKKRWFVLSENCLYYFDQMTDKEPKGI 309

  Fly   637 IPLENISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIK 701
            |.|.|:.:|::...|:|..||:|:..... ||||||:.:|::|||:|::|::.|..:||.:.||.
Worm   310 ITLANVGIRKVEAPSRPFMFEIFSLSDGQ-IKACKTEQDGRLVEGRHSIYKICAVNDEDMRSWIN 373

  Fly   702 RLTQSISHNPFYDILVQRK 720
            .:::.::  |...:|.:.|
Worm   374 AISRMMA--PQQHLLARPK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	75/179 (42%)
		PH_GRP1-like	592..710	CDD:269954	52/122 (43%)
		PH	596..708	CDD:278594	52/116 (45%)
grp-1	NP_498764.1	Sec7	60..241	CDD:238100	75/181 (41%)
		PH_GRP1-like	261..382	CDD:269954	52/123 (42%)
		PH	263..380	CDD:278594	52/117 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I3391
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1799
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		oto17273
orthoMCL	1	0.900	-	-		OOG6_103039
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5313
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690