DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and AgaP_AGAP001238

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_003435786.1	Gene:	AgaP_AGAP001238 / 1281933	VectorBaseID:	AGAP001238	Length:	1618	Species:	Anopheles gambiae

Alignment Length:	153	Identity:	34/153 - (22%)
Similarity:	61/153 - (39%)	Gaps:	46/153 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   592 FNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLEN--------------- 641
            ::....|:|.|:......|:.|||:|..|.|:|:|......|.|:|.||.
Mosquito    21 YDHSMHGYLHKRTSDNNKWQMRWFVLYQNLLFYYESEQSSRPSGLIFLEGCYCERLVSAPSISGP 85

  Fly   642 -ISV------REIHDRSKPHCFELFATGGADIIKAC-KTDSEGKVVEGKHTVYRMSAATEEDQQE 698
             ||.      :.|.:....|||.:           | :.:::.:        |.:.||||.:...
Mosquito    86 PISTSTGQAPKIIKEEKLQHCFTI-----------CYRRENQRQ--------YELRAATESECSA 131

  Fly   699 WIKRLTQSISHNPFYDILVQRKK 721
            ||..:.::    .|..:|:|:::
Mosquito   132 WIIAIREA----SFNKLLLQKEE 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680
		PH_GRP1-like	592..710	CDD:269954	31/140 (22%)
		PH	596..708	CDD:278594	31/134 (23%)
AgaP_AGAP001238	XP_003435786.1	PH_RasGRF1_2	19..166	CDD:270081	34/153 (22%)
		PH	25..140	CDD:278594	31/137 (23%)
		RhoGEF	278..459	CDD:214619
		PH-like	465..631	CDD:302622
		RasGEF_N	696..>748	CDD:279012
		REM	<1269..1331	CDD:100121
		RasGEF	1377..1555	CDD:279011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910