DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and AgaP_AGAP011421

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_317885.4	Gene:	AgaP_AGAP011421 / 1278273	VectorBaseID:	AGAP011421	Length:	1005	Species:	Anopheles gambiae

Alignment Length:	731	Identity:	186/731 - (25%)
Similarity:	273/731 - (37%)	Gaps:	221/731 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 NVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGDRNETPTMATPKSDIKIALKPPPK 150
            |||.|          ..||..||:.||  :..|.||.|.|                        .
Mosquito   308 NVSGA----------SSGSQLDSTVSS--MNLSWNSQTAS------------------------T 336

  Fly   151 PRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDVTTKVTEVQRLPCDEPNTELISKR 215
            .:||....||:...|    :.|..       :...:...|..:|.....:::|.:.|      ||
Mosquito   337 HQSPYTPHYTAAQIY----MRPRG-------IGIGSSGGSSGSTSSAGGRKVPPEVP------KR 384

  Fly   216 TEYKHTTIT-------TTTRTLIVSRPVELLLN-ENGEIIARRSPRKSRSNSLGRMLDVQNE-IG 271
            |    ::||       |.:|:|   ||..|... |||.:   .|.:.|.|:|......|..| ||
Mosquito   385 T----SSITGPGGQQHTPSRSL---RPNGLCKTAENGSL---SSVQSSGSDSSASAAGVGIEMIG 439

  Fly   272 TGGLFMEAD-----------PCSKNS----LPPPPYIDDMRFIDDSSNSQSESERNSNIHKTNKY 321
            .||....:|           |.|..|    |.|....|.|........:........:||.|...
Mosquito   440 GGGGGGSSDRSSSPQWKRKGPGSSQSGSITLLPAQSPDHMLLSATDGTTVVGGAAGRSIHSTVAT 504

  Fly   322 T-------------SKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDE 373
            .             |..|...:..||:    |.|..... ..|...||.|.:|
Mosquito   505 ATATATAASGAATGSSANVTITSIESE----CLSSHTSA-AQYSMMEQHDQIV------------ 552

  Fly   374 LCEVVSEMEALDVPEDCKHSN--KDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYK 436
                       ..|...|.|.  :.:|..:|...||..|::||.||:....|.:.||.||.||..
Mosquito   553 -----------HTPTSYKVSETIRKRQYRVGLNLFNKKPERGITYLIRKGFLENTPQGVARFLIT 606

  Fly   437 GEGLNKTAIGDYLGE-KNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMET 500
            .:||::..||:|||. :|.||..||..|....|.:.:.:..|||:|...||:|||||||:|:||.
Mosquito   607 RKGLSRQMIGEYLGNLQNQFNMAVLDCFAGELDLSGMQVDVALRKFQGYFRMPGEAQKIERLMEV 671

  Fly   501 FAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTV--DQFISMNRGINNGGDL 560
            |:.||||.|.||   ..:.||.:||:||||||||.||.|::|.:..:  |.|:...|||::..|:
Mosquito   672 FSARYCQCNSDIVARLRSHDTVFVLAFAIIMLNTDLHTPNLKPERRMRCDDFVKNLRGIDDCHDI 736

  Fly   561 PRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYF 625
            .|.:|..:||.::...||...|....:|                      |.:..|:.
Mosquito   737 DRDMLNGIYERVKANEFKPGSDHVTQVM----------------------KVQATIVG------- 772

  Fly   626 EYTTDKEPRGIIPLENI-------SVREIHDRSKP--HCFELFATGGADIIKACKTDSEGK---- 677
                 |:|...:|...:       .:.:|:.:.:|  |..|:|...  |::...|..|:.|
Mosquito   773 -----KKPNLALPHRRLVCYCRLYEIPDINKKERPGVHQREVFLFN--DLLVITKIFSKKKSSVT 830

  Fly   678 ------------------------------VVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPF 712
                                          .|:|| .:...:|..|.|:.::.:.|.:|||....
Mosquito   831 YTFRNSYTLCGMVVTLLDVPNYQFCIRLSQKVDGK-VLVTFNARNEHDRCKFAEDLRESISEMDE 894

  Fly   713 YDIL-----VQRKKKA 723
            .:.|     ::|:|.|
Mosquito   895 METLRIEAELERQKSA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	80/185 (43%)
		PH_GRP1-like	592..710	CDD:269954	24/160 (15%)
		PH	596..708	CDD:278594	22/154 (14%)
AgaP_AGAP011421	XP_317885.4	Sec7	565..753	CDD:279680	80/187 (43%)
AgaP_AGAP011421	XP_317885.4	PH_IQSEC	780..907	CDD:270128	21/129 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810