DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and AgaP_AGAP004989

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_001688613.1	Gene:	AgaP_AGAP004989 / 1275815	VectorBaseID:	AGAP004989	Length:	1729	Species:	Anopheles gambiae

Alignment Length:	424	Identity:	76/424 - (17%)
Similarity:	133/424 - (31%)	Gaps:	170/424 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PLLERGSGSDSSPSSVCVRCSCNSITKSGD-RNETPTMATPKSDIKIALKPPPKPRSPSMAPYTS 161
            ||.:||.|.......:..:    ||..|.| ||..|::....:...::|    :.|.||....:|
Mosquito  1018 PLDQRGGGGSGGSGGMLEK----SIAPSNDVRNTEPSVEEASTRFGVSL----RKREPSTDSCSS 1074

  Fly   162 --------VATYNITKLAPDSPPP------ASPTLSTQTVNC----------------------S 190
                    :.|.......|..|||      |.|...|....|                      |
Mosquito  1075 LGSPADAMINTVGDPSSLPIPPPPPAKDLKADPKRVTNVPKCLQGDVVGGKRTAGPLHGTSDPAS 1139

  Fly   191 DVTTKVTEVQRLP--------CDEP----NTELISKRTEYKHTTITTTTRTLIVSRPVEL----- 238
            .:.:::.|...||        ..||    ..:.||   .||.:.:::..:.:.:|:...|
Mosquito  1140 QLVSELAESMHLPKAPSPLTTAQEPQHHQQQQPIS---HYKSSDVSSLRKPVSMSKSTILPSTNA 1201

  Fly   239 LLNENGEI---------------------IARRSPRK--SRSNSLGRMLDVQNEI---------- 270
            ..|:|...                     .|:|:|.:  .:..|.|.::|.::.:
Mosquito  1202 AANDNYSAATNAASGVPQPPFKAQLKKVDTAKRAPAQPAKKEESTGGIIDFKSRLRKVDQNNTEV 1266

  Fly   271 ----GTGGLFMEADPCSKNSLPPPPYIDDMRFIDDSSNSQS-----ESERNSNIHKTNKYTSKN- 325
                |:|| ....||.:.|             :|:::..|:     :|..|:|.:.|....:.|
Mosquito  1267 SSNGGSGG-GESVDPPTSN-------------VDNNNKHQAGGNSLQSIHNNNFNTTASSNNSNG 1317

  Fly   326 ---NNNDSKRESQQS-----------------------------NLCESCRMLLDRNYIN----- 353
               ||||:...|..|                             ::..|.::||:.|.:|
Mosquito  1318 NILNNNDNSASSSSSENENHRSAKKGETGTPMVVRNGTSISGKNSMDSSNKLLLENNELNSLKLK 1382

  Fly   354 -----------TEQSDNLVILRRPSKQIKDELCE 376
                       |...|:..::.....:||.||.:
Mosquito  1383 KTNVASTIVTGTAPIDSNKVIELKKTEIKIELSD 1416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
step	NP_001036375.2	Sec7	397..577	CDD:279680
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
AgaP_AGAP004989	XP_001688613.1	SH3_Abl	123..177	CDD:212784
		SH2_ABL	182..277	CDD:198189
		PTKc_Abl	296..558	CDD:270645
		Pkinase_Tyr	303..554	CDD:285015
		F_actin_bind	1624..1729	CDD:286063
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910