DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and AgaP_AGAP011152

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_309496.4	Gene:	AgaP_AGAP011152 / 1270776	VectorBaseID:	AGAP011152	Length:	1232	Species:	Anopheles gambiae

Alignment Length:	694	Identity:	132/694 - (19%)
Similarity:	212/694 - (30%)	Gaps:	254/694 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 VNCSDVTTKVTEVQRLPCDEPNTELISKRTEYKHTTITTTTRTLIVSRPVEL----------LLN 241
            :||...|.|:.||    ..|.:|.   :|.|......|...:.||:. |..|          ..:
Mosquito   180 INCKISTAKLNEV----FHEVDTR---RRNELGFDDFTRLYQRLILP-PASLPEYFDGLRMATYS 236

  Fly   242 ENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFME-----------ADPCSKNSLPPPPYIDD 295
            :|||.:..:..|:..:..     ..::|...||...|           .||....|   .||:..
Mosquito   237 QNGETVTLQEFRRFLTKE-----QQEDEGSPGGGHSEETVAKFINDYIQDPARDVS---EPYLRL 293

  Fly   296 MRFIDDSSNSQSE--SERNSNIHKT--------------NKY-TSKNNNNDSKRESQQSNLCESC 343
            ..|||...:.|:|  .:|...:::.              |.| |....:::|..|:....|...|
Mosquito   294 HEFIDFLFSRQNEIWDKRCDTVYQDMSRPLAHYWISSSHNTYLTGDQFSSESSVEAYARALRMGC 358

  Fly   344 RML--------------------------------------LDRNY---INTEQSDNLVILRRPS 367
            |.:                                      :...|   ::.||:.:|...||
Mosquito   359 RCIELDCWDGPDNMPLIFHGHTFTTRIKFMDVIRTIKEHAFITSEYPLILSIEQNCSLTQQRR-- 421

  Fly   368 KQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRK---KFNMDPKKG---------------- 413
              :...:.||..|| .|..|.|...:.......:.||   |....|:.|
Mosquito   422 --MAQAMLEVFGEM-LLTQPIDKAEAQLPSPQQLKRKIILKHKKLPENGMLVVDEAGKESAVLMR 483

  Fly   414 --------IEYLVENRLL-RHDPQDV---AHFLY---------KGEGLNKTAIG-DYLGEKNDF- 455
                    |...|:|.:| ..||.|.   |||..         ..:..::.|.| |...|:|.|
Mosquito   484 GNDESELDIRNTVKNGILYLEDPVDKGWNAHFFVLTQHKLFYTDSQRPDRDADGRDDEREENGFA 548

  Fly   456 -----NEDVLKAFVALHDFTNLILVQALRQFLWSF-RLPGEAQKIDRMMETFAQRYCQLNPDIFT 514
                 .:..:.:...||...|           |.. :|.|..::.::::    |::..|....|.
Mosquito   549 TNRQSRDGAVLSNDELHFGEN-----------WFHGKLSGGREEAEKLL----QQFSHLGDGTFL 598

  Fly   515 NTDTC-----YVLSFAIIMLNTSLHNPSVKDKPTVDQF-ISMNRGINNGGDLPRGLLESLY---- 569
            ..::.     |.|||            ..:.||...:. :..::|:.....:...|.||||
Mosquito   599 VRESVTFVGDYCLSF------------WRQGKPNHCRIKLKQDKGVTKYYLMENVLFESLYSLIM 651

  Fly   570 ----ESIRTEPF------KIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYY 624
                .::|:..|      .:||            |:|.        ..|.|
Mosquito   652 YYRQNALRSAEFYITLKEPVPQ------------PNKH--------ETKEW-------------- 682

  Fly   625 FEYTTDKEPRGI----IPLEN-ISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVE---- 680
            :..||.:|...|    ||.:. ..||.....:|.......|.|.   .|.|:...||::.|
Mosquito   683 YHQTTTREQSEIVLNQIPQDGAFLVRPSEKGTKAFVISFRAHGK---FKHCRIRVEGRLYEMGGM 744

  Fly   681 ------------GKHTVYRMSAATEEDQQEWIKRL-TQSISHNP 711
                        .||.:||....|....:|.|:|: |..:|..|
Mosquito   745 EFESLVDLVNFYSKHPLYRKVTLTYPIPREMIRRINTMDVSCGP 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	43/241 (18%)
		PH_GRP1-like	592..710	CDD:269954	30/139 (22%)
		PH	596..708	CDD:278594	28/133 (21%)
AgaP_AGAP011152	XP_309496.4	PH_PLC_gamma	26..149	CDD:270168
		PH	38..140	CDD:278594
		EF-hand_like	234..316	CDD:286375	19/89 (21%)
		PI-PLCc_gamma	317..>463	CDD:176534	24/150 (16%)
		PH-like	497..>529	CDD:302622	8/31 (26%)
		SH2_N-SH2_PLC_gamma_like	565..663	CDD:199829	21/124 (17%)
		SH2_C-SH2_PLC_gamma_like	677..780	CDD:198186	26/127 (20%)
		SH3_PLCgamma	813..866	CDD:212759
		PLCYc	971..1084	CDD:128454
		C2_PLC_like	1103..1227	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910