DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Cyth2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_446363.1	Gene:	Cyth2 / 116692	RGDID:	620398	Length:	400	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	245/381 - (64%)
Similarity:	310/381 - (81%)	Gaps:	8/381 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 RMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFNM 408
            ||.|:.  |...:.:.||.::|    :::||.|.:||:|.|:..|..|...::::|::|||||||
  Rat    16 RMELEN--IRRRKQELLVEIQR----LREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNM 74

  Fly   409 DPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLI 473
            ||||||::|||:.||::.|:::|.|||||||||||||||||||:.:.|..||.|||.||:||:|.
  Rat    75 DPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLN 139

  Fly   474 LVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSV 538
            ||||||||||||||||||||||||||.||||||..||.:|.:||||||||||:||||||||||:|
  Rat   140 LVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNV 204

  Fly   539 KDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWK- 602
            :|||.:::|::||||||.|||||..||.:||:|||.||||||:||||||.|||||||:||||.|
  Rat   205 RDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKL 269

  Fly   603 QGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFATGG-ADI 666
            .|||.|:||||||||.|||||||||||||||||||||||:|:||:.|..||:||||:.... ..:
  Rat   270 GGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQL 334

  Fly   667 IKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKK 722
            ||||||:::|:||||.|.|||:||.|:|::.||||.:..::|.:|||::|..|||:
  Rat   335 IKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKR 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	130/179 (73%)
		PH_GRP1-like	592..710	CDD:269954	78/119 (66%)
		PH	596..708	CDD:278594	73/113 (65%)
Cyth2	NP_446363.1	Sec7	61..243	CDD:396096	130/181 (72%)
		PH_GRP1-like	258..378	CDD:269954	78/119 (66%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..276		4/7 (57%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	387..395		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1486
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1212
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm46031
orthoMCL	1	0.900	-	-		OOG6_103039
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820