DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and ARFGEF2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_006411.2	Gene:	ARFGEF2 / 10564	HGNCID:	15853	Length:	1785	Species:	Homo sapiens

Alignment Length:	257	Identity:	106/257 - (41%)
Similarity:	146/257 - (56%)	Gaps:	23/257 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 YINTEQSDNLVILRRPSKQIKD-------ELCEVVSEMEAL----------DVPEDCKHSNKDKQ 398
            |:|.....:|...|...::|.|       ..|.|.| ||:.          |.||..:...:.|:
Human   582 YVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTS-MESTVSSGTQTTVQDDPEQFEVIKQQKE 645

  Fly   399 -MSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKA 462
             :..|.:.||..||:||::|.|..:|....:|:|.||::.|.|:.|.:||:||:...||::|:.|
Human   646 IIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYA 710

  Fly   463 FVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY--CQLNPDIFTNTDTCYVLSFA 525
            :|...||.....|.|||.||..||||||||||||:||.||.||  |.....:|.:.||.|||:::
Human   711 YVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYS 775

  Fly   526 IIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDL 587
            ||||.|.||:|.||:|.|.:|:|.||||||:..|||...|.|:||.|  |..||...:..:|
Human   776 IIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEI--EGKKIAMKETKEL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	89/182 (49%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
ARFGEF2	NP_006411.2	DCB, DCB:DCB domain and DCB:HUS domain interaction	2..224
		PLN03076	11..1711	CDD:215560	106/257 (41%)
		DCB	28..198	CDD:292830
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..285
		Sec7_N	370..524	CDD:289549
		HUS, DCB:HUS domain interaction	508..528
		Sec7	643..827	CDD:279680	89/185 (48%)
		DUF1981	1167..1248	CDD:286414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1514..1535
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820