DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and gbf1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_031761940.1	Gene:	gbf1 / 100380093	XenbaseID:	XB-GENE-1012128	Length:	1890	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	122/467 - (26%)
Similarity:	209/467 - (44%)	Gaps:	92/467 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 SKNSLPPPPY--------IDDMRFIDDSSNSQSESERNSNIHKTNKYTSKNNNNDSKRESQQSNL 339
            |||:.|....        ::.:..:.||:.|..:::..||:.:..|.|.|.:.:.|:......||
Frog   603 SKNAFPVSGQLYTTHLLSLEALLTVIDSTESHCQAKNLSNVSQDKKETGKPSGDLSEGTKDSGNL 667

  Fly   340 CE---------------------SCRMLLDRNYINTEQSD------NLVILRRPSKQIKDELCEV 377
            .|                     |..::.|:..:..::::      ....|::|.:    ..|.:
Frog   668 NEHSIEVKPFTVSAENNGSKPPTSGHLMADKMTLGVQETEYSTDGGEKKTLKKPQR----FSCLL 728

  Fly   378 VSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLR--HDPQDVAHFLYKGEGL 440
            .:..|..|:      ..|.|.:..|.::||..||||:::|.|..||.  .|..:||.:|.:...|
Frog   729 PNVQELNDI------KTKKKLLITGTEQFNQKPKKGVQFLQEKDLLATPMDNAEVAQWLRENPRL 787

  Fly   441 NKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY 505
            :|..||:::.::.  |.|:|::||....|..|.:.:|||.:|.:|||||||..|.|::|.|.:.:
Frog   788 DKKMIGEFVSDRK--NLDLLESFVGTFHFQGLRVDEALRLYLEAFRLPGEAPVIQRLLEAFTEHW 850

  Fly   506 CQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDK---PTVDQFISMNRGINNGGDLPRGLLES 567
            .:.|...|.::|.|:.|::|:|||||..||.:|:.:   .|:::|....:|:|.|.|..:.:||.
Frog   851 RKSNGTPFAHSDACFALAYAVIMLNTDQHNHNVRKQNVPMTLEEFRKNLKGVNGGKDFDQDMLED 915

  Fly   568 LYESIRTEPFKIPQDD---------GNDLMHTFFNPDKEG-WLWKQGGRY------KSWKRRWFI 616
            :|.:|:.|...:|::.         .|.|:|....|  || :|....|.|      .:|......
Frog   916 IYHAIKNEEIVMPEEQTGLVKENYFWNVLLHRGATP--EGMFLHVDPGSYDHDLFTMTWGPTIAA 978

  Fly   617 LNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFATGGAD------IIKACK-TDS 674
            |:    |.|:.:.|         |.|..:.|....|  |..:.|..|..      ||..|| |..
Frog   979 LS----YVFDKSMD---------ETIIQKAISGFRK--CAMISAHYGLSDVFDNLIISLCKFTTL 1028

  Fly   675 EGKVVEGKHTVY 686
            ..:.||...||:
Frog  1029 SSEAVENLPTVF 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	67/184 (36%)
		PH_GRP1-like	592..710	CDD:269954	27/109 (25%)
		PH	596..708	CDD:278594	26/105 (25%)
gbf1	XP_031761940.1	COG5307	442..>1191	CDD:227623	122/467 (26%)
		Sec7	740..925	CDD:396096	68/186 (37%)
		PHA03247	<1753..1886	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920