DRSC/TRiP Functional Genomics Resources

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Protein Alignment step and arfgef2

DIOPT Version :10

Sequence 1:NP_001036375.2 Gene:step / 35425 FlyBaseID:FBgn0086779 Length:727 Species:Drosophila melanogaster
Sequence 2:XP_002666513.2 Gene:arfgef2 / 100334572 ZFINID:ZDB-GENE-090312-50 Length:1846 Species:Danio rerio


Alignment Length:629 Identity:167/629 - (26%)
Similarity:262/629 - (41%) Gaps:141/629 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PSISNWFSSLRRQPKNKKCSPGLGGSESVGRKQPLQRSCLDLSTTRVGCDGCVSLEFFQSESPES 73
            ||::.........|:    |....|||.:...:|  .|.|..|:...|.|        |....|:
Zfish   328 PSVTGGVEGEETHPQ----SETEAGSEVLEETEP--DSGLGDSSVEGGLD--------QHSDSET 378

  Fly    74 RRSNSTFYVNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGDRN--ETPTMAT 136
            |.......|:||.::..|  |:|        ||:||...:.......|.|.:...:  :......
Zfish   379 RMPPPVVRVDTQQMNGMV--DDR--------GSESSTDMLDAESIHGSQTAARFSHILQKDAFLV 433

  Fly   137 PKSDIKIALKP----PPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDV----- 192
            .:|..|:::||    ||.|:|..:.  :.|.:..:.......   |.|...|..:..:.:     
Zfish   434 FRSLCKLSMKPLADGPPDPKSHELR--SKVVSLQLLLSVLQG---AGPVFRTHEMFVNAIKQYLC 493

  Fly   193 -------TTKVTEVQRLPCDEPNT-------------------------ELISKRTEYKHTTITT 225
                   .:.|.||..|......|                         |..|...|:|...|.|
Zfish   494 VALSKNGVSSVPEVFELSLAIFLTLLSHFKVHLKMQIEVFFREIFLTILETSSSSFEHKWMVIQT 558

  Fly   226 TTRTLIVSR-PVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEI--GTGGLFMEADPCSKNSL 287
            .||....:: .|::.:|.:.::.|        :|...|:::..::|  |..|..:...|..:.||
Zfish   559 LTRICADAQCVVDIYVNYDCDLNA--------ANIFERLVNDLSKIAQGRSGQELGMTPLQELSL 615

  Fly   288 PPP-------------PYIDDMRFIDDSSNSQSESER----NSNIHKTNKYTSKNNNNDSKRESQ 335
            ...             .:..|| :::.:..:....||    :|...|.:::.|...::.|..:|.
Zfish   616 RKKGLECLVSILKCMVEWSRDM-YVNPNLQANLGQERPAEGDSADVKLSEHLSSRRDSVSSLDST 679

  Fly   336 QSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMS 400
            .|            :.:...|.|:            .|..||:.:.:     |..:|        
Zfish   680 VS------------SGVQQSQPDH------------PEQYEVIKQQK-----EIIEH-------- 707

  Fly   401 IGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVA 465
             |.:.||..||:|::||.|..:|...|:|:|.||.:.|.|:.|.:|::|||...||::|:..:|.
Zfish   708 -GIELFNKKPKRGLQYLQEQGMLGTSPEDIAQFLQQEERLDTTQVGEFLGENVKFNKEVMYCYVD 771

  Fly   466 LHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY--CQLNPDIFTNTDTCYVLSFAIIM 528
            ..||.....|.|||.||..||||||||||||:||.||.||  |.....:|.:.||.|||:::|||
Zfish   772 RLDFCGKDFVSALRAFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIM 836

  Fly   529 LNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESI 572
            |.|.||:|.||:|.|.:|:|.||||||:..|||...|.|:|:.|
Zfish   837 LTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEI 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stepNP_001036375.2 Sec7 395..577 CDD:460178 86/180 (48%)
PH_GRP1-like 592..710 CDD:269954
arfgef2XP_002666513.2 PLN03076 16..1760 CDD:215560 167/629 (27%)
Blue background indicates that the domain is not in the aligned region.

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