DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and fbxo8

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001120293.1	Gene:	fbxo8 / 100145349	XenbaseID:	XB-GENE-964650	Length:	316	Species:	Xenopus tropicalis

Alignment Length:	285	Identity:	78/285 - (27%)
Similarity:	126/285 - (44%)	Gaps:	47/285 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 NNNNDSKRESQQSNLCESCRMLLDRN------YINTEQSDNLVILRRPSKQIKDELCEVVSEMEA 383
            :|:|.:.|...|..: :.||:|..||      :||.|.....:.|...|.....:||  ::....
Frog    34 DNDNLNYRRQLQGGM-DICRLLKVRNAKDQQGFINLEMLPPELSLTILSYLNATDLC--LASCVW 95

  Fly   384 LDVPED-------CK----------------HSNKDKQMSI--GRKKFNMDPKKGIEYLVENRLL 423
            .|:..|       ||                .|.:|..|.:  |...||.:|..||||.:...:|
Frog    96 QDLANDEILWQGLCKSTWGHCSIYNKRHPLGFSFRDLYMRLDEGSLTFNANPHWGIEYFISRGIL 160

  Fly   424 RHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLP 488
            ....:::|.|::....||...:..||    |...|||...|.||:|:|..|..|||.|......|
Frog   161 DDSAKEIAKFIFCTRTLNWKNLRLYL----DRRRDVLDELVTLHNFSNQFLPNALRDFFRHIHAP 221

  Fly   489 GE-AQKIDRMMETFAQRYCQLNP----DIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFI 548
            .| .:.::.::..|:.|:|..||    |:..:.|..|||.:::|:|:..|.:|.||:|.:..:||
Frog   222 EERGEYLETLITKFSNRFCACNPALARDLGLSPDAVYVLCYSLILLSIDLASPHVKNKMSKREFI 286

  Fly   549 -SMNRGINNGGDLPRGLLESLYESI 572
             :..|...|   :....:..||::|
Frog   287 RNTRRAAQN---ISEDFVGHLYDNI 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	56/184 (30%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
fbxo8	NP_001120293.1	F-box-like	71..109	CDD:372399	6/39 (15%)
fbxo8	NP_001120293.1	Sec7	130..309	CDD:238100	57/186 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920