DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and cyth4b

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001108375.2	Gene:	cyth4b / 100141338	ZFINID:	ZDB-GENE-080219-45	Length:	395	Species:	Danio rerio

Alignment Length:	396	Identity:	236/396 - (59%)
Similarity:	299/396 - (75%)	Gaps:	7/396 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 ESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDK 397
            |...:.|....:|.::|..|:.:      ||....:::|.::..|:::::.....||.|...::|
Zfish     3 ECSDTELTVEEQMEIERLKIHKQ------ILLEDIEKLKSQIENVMADIQDFKSAEDNKTLEREK 61

  Fly   398 QMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKA 462
            :.|.|:|||||||||||.:||:|.||....:.||.||||.||||||||||:|||:.:.:..:|||
Zfish    62 RFSSGKKKFNMDPKKGIRFLVDNGLLDWKAERVAEFLYKEEGLNKTAIGDFLGEREEMHLQILKA 126

  Fly   463 FVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAII 527
            ||.||:|::|.||||||||||||||||||||||||||.||.|||..|..:|.:|||||:||||||
Zfish   127 FVELHEFSDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCNCNISVFQSTDTCYILSFAII 191

  Fly   528 MLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFF 592
            |||||||||:||||.|:::|||||||||||.|||..||.:||.|||.||||||:||||||.||||
Zfish   192 MLNTSLHNPNVKDKTTLERFISMNRGINNGEDLPDDLLTNLYNSIRNEPFKIPEDDGNDLTHTFF 256

  Fly   593 NPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFE 657
            |||:||||.|.|||.|:||||||||.|||||||||||||||||||||||:.|||:..:.||:|.|
Zfish   257 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLCVREVIFQRKPYCLE 321

  Fly   658 LF-ATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKK 721
            |: .......||||||:::|:||||||..|.:||:|.|::.:||:.:..||:.:||||::..|||
Zfish   322 LYNPNSRGQKIKACKTETDGRVVEGKHQSYTISASTAEERDQWIESIRASITKDPFYDLVSIRKK 386

  Fly   722 KALSKS 727
            |...|:
Zfish   387 KVTGKA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	127/179 (71%)
		PH_GRP1-like	592..710	CDD:269954	74/118 (63%)
		PH	596..708	CDD:278594	69/112 (62%)
cyth4b	NP_001108375.2	Sec7	59..241	CDD:279680	127/181 (70%)
		PH_GRP1-like	256..375	CDD:269954	74/118 (63%)
		PH	260..372	CDD:278594	68/111 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm25514
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060