DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and rasa1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001107303.1	Gene:	rasa1 / 100135092	XenbaseID:	XB-GENE-6085075	Length:	946	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	73/344 - (21%)
Similarity:	133/344 - (38%)	Gaps:	105/344 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 KGIEYLVENRLLRHDPQD----VAHFLYKGEGLNKTAIGDYLGEKNDFNEDVL--KAFVALHDFT 470
            ||..::|.|.|     :|    |.:.....:||....:...:|.:.|.:|..:  ...::..:..
Frog   202 KGDMFIVHNEL-----EDGWLWVTNLRTNEQGLIVEDLVKEVGREEDPHEGKIWFHGKISKQEAY 261

  Fly   471 NLIL-VQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLH 534
            ||:: |..:..||                         :.|.  .||...|.|.|     .|:.:
Frog   262 NLLMTVGGISSFL-------------------------VRPS--DNTPGDYSLYF-----RTNEN 294

  Fly   535 NPSVKDKPTV-DQFISMNRGINNGGDL-----PRGLLESLYESIRTEPFKIPQD--------DGN 585
            ....|..||. :||:...|..|:..|:     ...::|..|   ..:|..:...        ||.
Frog   295 IQRFKICPTANNQFMMGGRYYNSIDDIIDHYRKEQIVEGYY---LKQPVPVQHQEQVLNDFLDGK 356

  Fly   586 DLMHT---------FFNPDKEGWLWKQGGRYKSWKRRWFIL--NDNCLYYFEYTTDK---EPRGI 636
            ::.:|         :.|..|:|:|.|: .:.|.||..:|||  ||..|.:||  ::|   :|:|:
Frog   357 EIYNTIKRRTKDAFYKNIVKKGYLLKK-SKGKRWKNLYFILEGNDAQLIFFE--SEKRATKPKGL 418

  Fly   637 IPLENISVREIHDR--SKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEW 699
            ..|...||..:||.  .:|:||::.....::                :|.::..:..|.|..::|
Frog   419 FDLSVCSVYVVHDSLFGRPNCFQIVVQHFSE----------------EHYIFYFACDTPEQAEDW 467

  Fly   700 ---------IKRLTQSISH 709
                     ::::|||.|:
Frog   468 MRTLQAFCCLRKITQSPSN 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	34/177 (19%)
		PH_GRP1-like	592..710	CDD:269954	35/134 (26%)
		PH	596..708	CDD:278594	33/127 (26%)
rasa1	NP_001107303.1	SH2_Nterm_RasGAP	60..163	CDD:198216
		SH3_RasGAP	180..238	CDD:212722	9/40 (23%)
		SH2_Cterm_RasGAP	249..325	CDD:198217	20/107 (19%)
		PH_RASA1	372..475	CDD:270080	31/121 (26%)
		PH	374..475	CDD:278594	30/119 (25%)
		C2_Ras_p21A1	490..615	CDD:176045
		RasGAP	597..939	CDD:214617
		RasGAP_p120GAP	613..944	CDD:213340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910