DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and cyth3a

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_001342037.2	Gene:	cyth3a / 100002190	ZFINID:	ZDB-GENE-120612-1	Length:	396	Species:	Danio rerio

Alignment Length:	397	Identity:	253/397 - (63%)
Similarity:	319/397 - (80%)	Gaps:	11/397 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 NLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKD-------ELCEVVSEMEALDVPEDCKHSNK 395
            |:.|..|:..|.::   |:.|.|..:||..:::.|       |:.||::|:|.|....:.|.:.:
Zfish     2 NMDEDNRVPEDLSF---EERDELSNIRRRKRELLDDIERLKLEISEVMTEIEHLTCVRETKSTQR 63

  Fly   396 DKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVL 460
            .||:::|||||||||||||::|:||.||:|.|:|:|.|||||||||||.|||||||::|||..||
Zfish    64 SKQIAVGRKKFNMDPKKGIQFLLENDLLQHTPEDIAQFLYKGEGLNKTVIGDYLGERDDFNIRVL 128

  Fly   461 KAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFA 525
            :|||.||:|.:|.||||||||||||||||||||||||||.:|.||||.||.:|.:|||||||||:
Zfish   129 QAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAYAARYCQCNPGVFQSTDTCYVLSFS 193

  Fly   526 IIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHT 590
            :||||||||||:|:|||:|::|||||||||.|||||..||.:|||||:.||||||:||||||.||
Zfish   194 VIMLNTSLHNPNVRDKPSVERFISMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHT 258

  Fly   591 FFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHC 655
            |||||:||||.|.|||.|:||||||||.|||||||||||||||||||||||:|:||:.:..||:|
Zfish   259 FFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEEPRKPNC 323

  Fly   656 FELF-ATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQR 719
            |||: .:....:||||||:::||||||.|.|||:||.|.|:::||||.:..|||.:||||:|..|
Zfish   324 FELYNPSHKGQVIKACKTEADGKVVEGNHVVYRISAPTPEEKEEWIKSIKASISRDPFYDMLATR 388

  Fly   720 KKKALSK 726
            |::..:|
Zfish   389 KRRVATK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	134/179 (75%)
		PH_GRP1-like	592..710	CDD:269954	80/118 (68%)
		PH	596..708	CDD:278594	74/112 (66%)
cyth3a	XP_001342037.2	Sec7	63..245	CDD:279680	134/181 (74%)
		PH_GRP1-like	260..379	CDD:269954	80/118 (68%)
		PH	264..377	CDD:278594	74/112 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I1419
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm25514
orthoMCL	1	0.900	-	-		OOG6_103039
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17306
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.850