DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS1

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens


Alignment Length:571 Identity:142/571 - (24%)
Similarity:207/571 - (36%) Gaps:187/571 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSVNMNWTSPKIW---AALFVTTL-------CLLDTQAAWAKKLNASQAFDDTWNTASDLENEL- 54
            |..|::.:.|  |   :|..:|:.       ||:|      |..|..|...|...|:.|...:. 
Human   433 MLSNLDHSQP--WSPCSAYMITSFLDNGHGECLMD------KPQNPIQLPGDLPGTSYDANRQCQ 489

  Fly    55 ----EQQKR--------SKVQSAGGGGG----------------AGGGP---------------- 75
                |..|.        |.:...|..||                .|.|.                
Human   490 FTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHF 554

  Fly    76 -----GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCPEQ--Q 127
                 |.|..|..|..|||||.||:.:.||.|.:|     |. |.|:..|||.||::.||:.  :
Human   555 DTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619

  Fly   128 DFRSSQCSAYNDVPY----DGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEE 185
            .||..||.|:|:...    .|...:|.|.|..|.|   |.|.|:.            .|.|    
Human   620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQA------------KGIG---- 668

  Fly   186 AEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC- 249
                    ....|..:|.|||.|...|..:|:||:|.:.|||..|.|.||.|.||||||:|::| 
Human   669 --------YFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCK 725

  Fly   250 --------SQPLF-----------NWEMAPMSQ---------CSVTCGSG--------------- 271
                    ::|.:           |.|:...:|         .::....|               
Human   726 KISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790

  Fly   272 ---YK---------------------MSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCP 312
               ||                     :..|:....||..:........|...:...|..|.....
Human   791 DIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTF 855

  Fly   313 PRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVED 377
            ..|:.::|..||:.|..|::.|:|.|.:    |..:.|....:..||.:...|....||.|::.:
Human   856 SAWVIEEWGECSKSCELGWQRRLVECRD----INGQPASECAKEVKPASTRPCADHPCPQWQLGE 916

  Fly   378 WTGCSVSCGQGIQMRGVECKSTDGSLSA--KCDPLTKPG------SMQQCS 420
            |:.||.:||:|.:.|.::|.|.||.:.:  .||||.||.      :|.:||
Human   917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 22/51 (43%)
TSP1 546..600 CDD:214559
TSP1 750..807 CDD:214559
IGc2 845..902 CDD:197706
PLAC 1355..1384 CDD:285849
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Pep_M12B_propep 66..166 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250
Cysteine switch. /evidence=ECO:0000250 196..203
Reprolysin 258..467 CDD:279729 9/41 (22%)
ZnMc_ADAMTS_like 258..463 CDD:239801 6/31 (19%)
ADAM_CR 468..548 CDD:301627 13/79 (16%)
TSP1 562..614 CDD:214559 22/51 (43%)
Spacer 725..849 12/123 (10%)
ADAM_spacer1 725..842 CDD:283607 11/116 (9%)
TSP1 858..910 CDD:214559 14/55 (25%)
TSP1 912..967 CDD:214559 19/54 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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