DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS2

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_055059.2 Gene:ADAMTS2 / 9509 HGNCID:218 Length:1211 Species:Homo sapiens


Alignment Length:823 Identity:180/823 - (21%)
Similarity:264/823 - (32%) Gaps:336/823 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.:||.:.:|||||..|:..:.|:|.:|      .:|.|.:..:::|:.|.||:. .|||..|
Human   562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQ 626

  Fly   134 CSAYNDVPYD--GTLYKWTP--HYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            |..: |:.::  ...:.|.|  |.|..|.|.|.|.          |||||:              
Human   627 CRQW-DLYFEHGDAQHHWLPHEHRDAKERCHLYCE----------SRETGE-------------- 666

  Fly   195 IVQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEM 258
            :|.:...|.|||||. ..:..:|::|.|::||||..|||:|:.|.|||||||.:.|......:..
Human   667 VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTR 731

  Fly   259 APMSQCSVTCGSGY-KMSR-PICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWS 321
            :|...       || ||.. |.....|...:||                               :
Human   732 SPKKH-------GYIKMFEIPAGARHLLIQEVD-------------------------------A 758

  Fly   322 TCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCG 386
            |...|..........:..||::      .|...:|         .|.....||..|         
Human   759 TSHHLAVKNLETGKFILNEEND------VDASSKT---------FIAMGVEWEYRD--------- 799

  Fly   387 QGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSR-SLNERSER 450
                ..|.|...|.|.|......|..|                        ||.:| ||..:...
Human   800 ----EDGRETLQTMGPLHGTITVLVIP------------------------VGDTRVSLTYKYMI 836

  Fly   451 QLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMH 515
            ..||.:.|::|..|.|.                         ::|....:               
Human   837 HEDSLNVDDNNVLEEDS-------------------------VVYEWALK--------------- 861

  Fly   516 LMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVND 580
                                          :|||||..||.|.:...|.|:..|:          
Human   862 ------------------------------KWSPCSKPCGGGSQFTKYGCRRRLD---------- 886

  Fly   581 SLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGV 645
                    |..|.|           ||                                      
Human   887 --------HKMVHR-----------GF-------------------------------------- 894

  Fly   646 EELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC-PPRWNYSDYTPCSKSCG-IGIKTRE 708
                                |:..:||:|..|.||.:.| .|.|...::.|||::|| .|::.|.
Human   895 --------------------CAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRS 939

  Fly   709 VQCI---HEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRK 770
            |:||   |:.|     |..|....|....|..|:.|:...||.||..|.||:||.|||.|.::|.
Human   940 VRCIQPLHDNT-----TRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERP 999

  Fly   771 VECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCP------------------PEDPKPVIQI 817
            |.|:       ..:....:|...:|...:.|.:.|||                  |:...|:.:|
Human  1000 VLCR-------TADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKI 1057

  Fly   818 NNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIK-CPVKRYNR 859
            ::..|.|.|..             :|...:|..: |.:..||:
Human  1058 SSKGHCQGDKS-------------IFCRMEVLSRYCSIPGYNK 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 16/51 (31%)
TSP1_ADAMTS 256..311 CDD:465950 9/56 (16%)
TSP1_ADAMTS 315..370 CDD:465950 7/54 (13%)
TSP1_ADAMTS 373..420 CDD:465950 10/46 (22%)
TSP1 546..600 CDD:214559 14/53 (26%)
TSP1_ADAMTS 629..684 CDD:465950 7/54 (13%)
TSP1_ADAMTS 688..746 CDD:465950 19/61 (31%)
TSP1_ADAMTS 750..806 CDD:465950 16/55 (29%)
Ig 845..914 CDD:472250 4/16 (25%)
Ig strand B 848..852 CDD:409353 1/4 (25%)
Ig strand C 861..865 CDD:409353
Ig strand E 883..887 CDD:409353
Ig strand F 897..902 CDD:409353
TSP1_ADAMTS 1157..1227 CDD:465950
TSP1_ADAMTS 1289..1343 CDD:465950
PLAC 1355..1384 CDD:462560
ADAMTS2NP_055059.2 Pep_M12B_propep 91..212 CDD:460254
ZnMc_ADAMTS_like 266..467 CDD:239801
ADAMTS_CR_2 482..551 CDD:465496
TSP1 564..616 CDD:214559 16/51 (31%)
ADAMTS_CR_3 621..722 CDD:437068 45/125 (36%)
Cell attachment site. /evidence=ECO:0000255 691..693 0/1 (0%)
Spacer 723..851 35/217 (16%)
ADAMTS_spacer1 724..837 CDD:461796 31/202 (15%)
TSP1_ADAMTS 858..913 CDD:465950 23/186 (12%)
TSP1_ADAMTS 918..975 CDD:465950 19/61 (31%)
TSP1_ADAMTS 979..1028 CDD:465950 16/55 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1191
Blue background indicates that the domain is not in the aligned region.

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