DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS2

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_055059.2 Gene:ADAMTS2 / 9509 HGNCID:218 Length:1211 Species:Homo sapiens


Alignment Length:823 Identity:180/823 - (21%)
Similarity:264/823 - (32%) Gaps:336/823 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.:||.:.:|||||..|:..:.|:|.:|      .:|.|.:..:::|:.|.||:. .|||..|
Human   562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQ 626

  Fly   134 CSAYNDVPYD--GTLYKWTP--HYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            |..: |:.::  ...:.|.|  |.|..|.|.|.|.          |||||:              
Human   627 CRQW-DLYFEHGDAQHHWLPHEHRDAKERCHLYCE----------SRETGE-------------- 666

  Fly   195 IVQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEM 258
            :|.:...|.|||||. ..:..:|::|.|::||||..|||:|:.|.|||||||.:.|......:..
Human   667 VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTR 731

  Fly   259 APMSQCSVTCGSGY-KMSR-PICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWS 321
            :|...       || ||.. |.....|...:||                               :
Human   732 SPKKH-------GYIKMFEIPAGARHLLIQEVD-------------------------------A 758

  Fly   322 TCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCG 386
            |...|..........:..||::      .|...:|         .|.....||..|         
Human   759 TSHHLAVKNLETGKFILNEEND------VDASSKT---------FIAMGVEWEYRD--------- 799

  Fly   387 QGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSR-SLNERSER 450
                ..|.|...|.|.|......|..|                        ||.:| ||..:...
Human   800 ----EDGRETLQTMGPLHGTITVLVIP------------------------VGDTRVSLTYKYMI 836

  Fly   451 QLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMH 515
            ..||.:.|::|..|.|.                         ::|....:               
Human   837 HEDSLNVDDNNVLEEDS-------------------------VVYEWALK--------------- 861

  Fly   516 LMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVND 580
                                          :|||||..||.|.:...|.|:..|:          
Human   862 ------------------------------KWSPCSKPCGGGSQFTKYGCRRRLD---------- 886

  Fly   581 SLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGV 645
                    |..|.|           ||                                      
Human   887 --------HKMVHR-----------GF-------------------------------------- 894

  Fly   646 EELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC-PPRWNYSDYTPCSKSCG-IGIKTRE 708
                                |:..:||:|..|.||.:.| .|.|...::.|||::|| .|::.|.
Human   895 --------------------CAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRS 939

  Fly   709 VQCI---HEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRK 770
            |:||   |:.|     |..|....|....|..|:.|:...||.||..|.||:||.|||.|.::|.
Human   940 VRCIQPLHDNT-----TRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERP 999

  Fly   771 VECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCP------------------PEDPKPVIQI 817
            |.|:       ..:....:|...:|...:.|.:.|||                  |:...|:.:|
Human  1000 VLCR-------TADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKI 1057

  Fly   818 NNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIK-CPVKRYNR 859
            ::..|.|.|..             :|...:|..: |.:..||:
Human  1058 SSKGHCQGDKS-------------IFCRMEVLSRYCSIPGYNK 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 16/51 (31%)
TSP1 546..600 CDD:214559 14/53 (26%)
TSP1 750..807 CDD:214559 17/56 (30%)
IGc2 845..902 CDD:197706 4/16 (25%)
PLAC 1355..1384 CDD:285849
ADAMTS2NP_055059.2 Pep_M12B_propep 100..211 CDD:279848
ZnMc_ADAMTS_like 266..467 CDD:239801
Reprolysin 268..470 CDD:279729
TSP1 564..616 CDD:214559 16/51 (31%)
Cell attachment site. /evidence=ECO:0000255 691..693 0/1 (0%)
Spacer 723..851 35/217 (16%)
ADAM_spacer1 723..837 CDD:283607 31/203 (15%)
TSP1 863..914 CDD:214559 23/137 (17%)
TSP1 917..976 CDD:214559 19/63 (30%)
TSP1 982..1029 CDD:214559 16/53 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1191
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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