DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS3

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_055058.2 Gene:ADAMTS3 / 9508 HGNCID:219 Length:1205 Species:Homo sapiens


Alignment Length:963 Identity:205/963 - (21%)
Similarity:314/963 - (32%) Gaps:395/963 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 WNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP--- 105
            |..|:       |||:.               |.|.||:.:.:|||||..|:..:.|:|.:|   
Human   542 WKNAN-------QQKQD---------------GNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPI 584

  Fly   106 ---GSCRGESTRYRICNMQPCPEQ-QDFRSSQCSAYND-VPYDGTLYKWTPHYDYVEP---CALT 162
               ..|.|.:..|::||.:.|.:. :|||:.||...|. ..|..|.:.|.| |::.:|   |.|.
Human   585 NGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLP-YEHPDPKKRCHLY 648

  Fly   163 CRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCR-SGSLDMCIQGKCQRVGC 226
            |:          |:||||              :..:...|.|||.|. .....:|::|:|.:|||
Human   649 CQ----------SKETGD--------------VAYMKQLVHDGTHCSYKDPYSICVRGECVKVGC 689

  Fly   227 DLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDT 291
            |.:|||.|..|.|||||||.               |.|....|                      
Human   690 DKEIGSNKVEDKCGVCGGDN---------------SHCRTVKG---------------------- 717

  Fly   292 LCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRT 356
                            |.:..||.:             ||               .::.||    
Human   718 ----------------TFTRTPRKL-------------GY---------------LKMFDI---- 734

  Fly   357 PKPPTQETCIIEE---CPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQ 418
              ||.....:|:|   .||                             .|:.|            
Human   735 --PPGARHVLIQEDEASPH-----------------------------ILAIK------------ 756

  Fly   419 CSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNE-DENDEGDDVDDLESGQDTDD 482
                       |:..|..|      ||.:.|.....:..|...| |.|.|    ||:||      
Human   757 -----------NQATGHYI------LNGKGEEAKSRTFIDLGVEWDYNIE----DDIES------ 794

  Fly   483 GEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYI----K 543
                                           :|                ::||..||..:    :
Human   795 -------------------------------LH----------------TDGPLHDPVIVLIIPQ 812

  Fly   544 DNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFD 608
            :|:            .|.:...| ::.:..:|.|:|.:..                         
Human   813 END------------TRSSLTYK-YIIHEDSVPTINSNNV------------------------- 839

  Fly   609 DQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPE 673
                       :.|...|:.|..:.::.||..|.||.:.....|.|:.:.::|....|....||:
Human   840 -----------IQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPK 893

  Fly   674 ARVRTCNDRPCP-PRWNYSDYTPCSKSCG-IGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPA 736
            ...|.||.:.|. |.|...::..|:|:|| .|.:.|.|:|:..:..|.:.:  |.:..|....|.
Human   894 PIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRS--VHSKYCMGDRPE 956

  Fly   737 DRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPC 801
            .|:.||.:.||.:|:.|.||:||.|||.|.:.|:|.|:   |.:|        |...||...:.|
Human   957 SRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR---AGDH--------CDGEKPESVRAC 1010

  Fly   802 NVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIK-CPVKRYNRTKIKWS 865
            .:.||..|   |.:                      |...:|...:|..: |.:..||:...:  
Human  1011 QLPPCNDE---PCL----------------------GDKSIFCQMEVLARYCSIPGYNKLCCE-- 1048

  Fly   866 KDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETE 930
                        ..||:.:      |.....:      |.:||...:|.:.|......|....: 
Human  1049 ------------SCSKRSS------TLPPPYL------LEAAETHDDVISNPSDLPRSLVMPTS- 1088

  Fly   931 RLVREKSGTEA--LTSADMKSADGTGTSTAVGPNSHVNG------SAQQHGSR 975
             ||...|.|.|  ::.:.:.|..|.....|..|||..:|      ||||.||:
Human  1089 -LVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 17/51 (33%)
TSP1_ADAMTS 256..311 CDD:465950 4/54 (7%)
TSP1_ADAMTS 315..370 CDD:465950 8/57 (14%)
TSP1_ADAMTS 373..420 CDD:465950 2/46 (4%)
TSP1 546..600 CDD:214559 5/53 (9%)
TSP1_ADAMTS 629..684 CDD:465950 15/54 (28%)
TSP1_ADAMTS 688..746 CDD:465950 16/58 (28%)
TSP1_ADAMTS 750..806 CDD:465950 19/55 (35%)
Ig 845..914 CDD:472250 10/69 (14%)
Ig strand B 848..852 CDD:409353 1/4 (25%)
Ig strand C 861..865 CDD:409353 0/3 (0%)
Ig strand E 883..887 CDD:409353 0/3 (0%)
Ig strand F 897..902 CDD:409353 0/4 (0%)
TSP1_ADAMTS 1157..1227 CDD:465950
TSP1_ADAMTS 1289..1343 CDD:465950
PLAC 1355..1384 CDD:462560
ADAMTS3NP_055058.2 Pep_M12B_propep 43..201 CDD:460254
ZnMc_ADAMTS_like 256..457 CDD:239801
ADAMTS_CR_2 472..540 CDD:465496
TSP1 554..605 CDD:214559 17/50 (34%)
ADAMTS_CR_3 611..712 CDD:437068 45/140 (32%)
Spacer 713..844 43/366 (12%)
ADAMTS_spacer1 714..827 CDD:461796 39/312 (13%)
TSP1_ADAMTS 849..904 CDD:465950 15/54 (28%)
TSP1_ADAMTS 909..966 CDD:465950 16/58 (28%)
TSP1_ADAMTS 970..1015 CDD:465950 19/55 (35%)
PLAC 1023..1051 CDD:462560 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1205
Blue background indicates that the domain is not in the aligned region.

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