DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTSL1

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:XP_011516365.1 Gene:ADAMTSL1 / 92949 HGNCID:14632 Length:1828 Species:Homo sapiens


Alignment Length:1914 Identity:438/1914 - (22%)
Similarity:648/1914 - (33%) Gaps:730/1914 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQ 98
            ||:.:..|.:..||...|:.                     .|.|.:|..||.|||||.||..:.
Human    79 LNSHKTEDSSSRTARSEEDR---------------------DGLWDAWGPWSECSRTCGGGASYS 122

  Fly    99 MRRCGSPGSCRGESTRYRICNMQPC-PEQQDFRSSQCSAYNDVPYDGTLYKWTP-HYDYVEPCAL 161
            :|||.|..||.|.:.|||.|:...| ||..|||:.||||:|||.:.|..|:|.| ..|...||:|
Human   123 LRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSL 187

  Fly   162 TCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGC 226
            .|:.....||                        |:|:.:|.|||||.:.||||||.|.||.|||
Human   188 KCQAKGTTLV------------------------VELAPKVLDGTRCYTESLDMCISGLCQIVGC 228

  Fly   227 DLKIGSTKKIDGCGVCGGDGNSCS----------------------------------------- 250
            |.::|||.|.|.||||.|||::|.                                         
Human   229 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYL 293

  Fly   251 ----------------------------------------------------------------- 250
                                                                             
Human   294 ETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI 358

  Fly   251 --QPLFN-WEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSV---TNRPEASVEQCNTH 309
              ||:.: |.......||.|||.||:::...|.:..:|..|.|..|..   ..:|:..:::||..
Human   359 FYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 423

  Fly   310 SCP-----------------PRWIADDWSTCSRLCGHGYRERMVVCAEES-NGIKTRVADIMCR- 355
            .||                 |||.|..|:.||..||.|.:.|.|.|.||. .|..|.|.:..|. 
Human   424 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMY 488

  Fly   356 TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCS 420
            |||.|..:.|.|.:||.|..::|:.|:|:||||::.|.|.|....|..:..|.|.|||...::|.
Human   489 TPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECI 553

  Fly   421 TGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEG 485
            ....|                                                            
Human   554 VPTPC------------------------------------------------------------ 558

  Fly   486 LSYADQPLLYAHRTQSRLNQEA--PDEPRTMHLMNGNSNNNFNRGEDESEGPSL--DPTYIKDNE 546
                       ::.:.:|..||  |               .|.:.::..||.::  :|::|.: .
Human   559 -----------YKPKEKLPVEAKLP---------------WFKQAQELEEGAAVSEEPSFIPE-A 596

  Fly   547 WSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCM--LPSHGFDD 609
            ||.|:||||.|.:.|...|::.|.:|::||.:....|||.||..: ..|...||.  :|....|:
Human   597 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQ-RACYAGPCSGEIPEFNPDE 660

  Fly   610 QFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEA 674
               .|.:..|:.:..:.|.|..:|:|.||.||.|||:|.:::|:.:.........||....:|..
Human   661 ---TDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQ 722

  Fly   675 RVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQ 739
            .:::||..|||.||....::|||.:||:|::||:|.|.|.::|..:.|:::.:.:|.||.|:..|
Human   723 LLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQ 787

  Fly   740 YCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVK 804
            .||..:||..|...:|..||.|||.|.:.|:|.|||.||....:|.||:.|.::|||.::.|...
Human   788 ACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKD 852

  Fly   805 PCPPE-----------------DPKPVI----------QINNST--------------------- 821
            .||.|                 ..:..|          .:.|||                     
Human   853 DCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR 917

  Fly   822 ----HIQHDP-------------KKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHK 869
                ..:|.|             ::.|:...|||...:...|.|.::||.:|..:..|.|.||.:
Human   918 PGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKDGQ 982

  Fly   870 PLQRSRKYKVSKKGALRILDITFRDAGVYSCHAG---------------------LS-------- 905
            .|..|....|:..|.|:|..:...|||||:|.||                     ||        
Human   983 HLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPLSPRSEEEVL 1047

  Fly   906 ----------------------------------------------------------------- 905
                                                                             
Human  1048 AGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLEQGGWPGELLASWEAQD 1112

  Fly   906 SAEISIEVKAKPG---------------------------QQIEELEQQETERLVRE------KS 937
            |||.:...:..||                           ||.|||....::.||.:      :|
Human  1113 SAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQPEELRDLYSKHLVAQLAQEIFRS 1177

  Fly   938 GTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQ----------HGSRRRQQQSERLQNGRERSR 992
            ..|...:. :|.::...:...:.|:.||:|.:..          .||||..::...|:......:
Human  1178 HLEHQDTL-LKPSERRTSPVTLSPHKHVSGFSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQ 1241

  Fly   993 RPKSDGVQHADSSI--MEDDLSQL---------------------VQSEDRI------------- 1021
            ...|:.|.|...::  ....||.|                     ||..|||             
Human  1242 LSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAP 1306

  Fly  1022 -------------------------------------------PQPASASSGGSRTRTL----LA 1039
                                                       .:||.....||..:|:    :.
Human  1307 VEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVT 1371

  Fly  1040 MPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAE--------- 1095
            :....|.:...::.|...:.|.....||.:|..|...:..|.:......:..:..|         
Human  1372 INCQVAGVPEAEVTWFRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLI 1436

  Fly  1096 ----QLP-----------------PEVLHSP------SDPEYHE----PSKSGPEADVPHVPPHM 1129
                |:|                 |.||.||      .||....    |.|..|          :
Human  1437 LDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHP----------V 1491

  Fly  1130 PHARWETGAAASTTAV------------------------------------------------- 1145
            |:..|..|.....||.                                                 
Human  1492 PNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYW 1556

  Fly  1146 ----------PSLPNDGFVY-------------------------------------RWMLGEWS 1163
                      .|..|.|...                                     |||:..||
Human  1557 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWS 1621

  Fly  1164 QCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACP 1228
            .|::.|   |.|:|.|.|:||   |..:||.::.     |.|..| ....:.|...|:|..:.|.
Human  1622 ACTRSC---GGGVQTRRVTCQ---KLKASGISTP-----VSNDMC-TQVAKRPVDTQACNQQLCV 1674

  Fly  1229 QWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNG--TEGSICDEYERPAMRQECYNERCEGVWRV 1291
            :|:...|..| ...|.|.:.|:|.|:|.|:..:|  .....|....||...|.|::|.|...|||
Human  1675 EWAFSSWGQC-NGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRV 1738

  Fly  1292 EPWSECNAPCGRKGIKYRILQCVWYGSRRPA-GNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLC 1355
            ..|:.|.|.||..|.:.|.::||...:.:.. .::|...||||..:.|....|:       ...|
Human  1739 SLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCE-------NMEC 1796

  Fly  1356 RDSSRYCRNARAMGLCRLHRYKLKCCGSC 1384
            ||::|||...:.:.||:|.::|.:|||:|
Human  1797 RDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 23/46 (50%)
TSP1 546..600 CDD:214559 20/53 (38%)
TSP1 750..807 CDD:214559 23/56 (41%)
IGc2 845..902 CDD:197706 21/56 (38%)
PLAC 1355..1384 CDD:285849 13/28 (46%)
ADAMTSL1XP_011516365.1 TSP1 102..148 CDD:214559 22/45 (49%)
TSP1 446..504 CDD:214559 23/57 (40%)
TSP1 510..>539 CDD:214559 11/28 (39%)
TSP1 597..650 CDD:214559 21/53 (40%)
TSP1 736..795 CDD:214559 21/58 (36%)
TSP_1 801..854 CDD:278517 22/52 (42%)
TSP1 856..915 CDD:214559 5/58 (9%)
IGc2 957..1015 CDD:197706 21/57 (37%)
Ig 1263..1323 CDD:299845 7/59 (12%)
IG_like 1352..1436 CDD:214653 14/83 (17%)
IGc2 1366..1426 CDD:197706 8/59 (14%)
I-set 1461..1552 CDD:254352 15/100 (15%)
IGc2 1476..1542 CDD:197706 9/75 (12%)
TSP1 1618..1673 CDD:214559 20/66 (30%)
PLAC 1796..1825 CDD:285849 13/28 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 65 1.000 Domainoid score I10044
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 546 1.000 Inparanoid score I1161
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26058at33208
OrthoFinder 1 1.000 - - FOG0004452
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_106353
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7766
SonicParanoid 1 1.000 - - X3156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.860

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