DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and PAPLN

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens


Alignment Length:1520 Identity:316/1520 - (20%)
Similarity:448/1520 - (29%) Gaps:625/1520 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 WSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GSCRGESTRYRICNMQPCPE-QQDFRSSQCSA 136
            |..||.||.|||||.||:..:.|.|.|.     .||.|.:..:|.|..:.||: .:|||:.||:.
Human    29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAE 93

  Fly   137 YNDVPYDGTLYKWTPHYDYVEPCALTC--RGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLS 199
            ::...:.|..|:|.|:|.....|.|.|  :|                   |..:|..:..:|   
Human    94 FDGAEFQGRRYRWLPYYSAPNKCELNCIPKG-------------------ENFYYKHREAVV--- 136

  Fly   200 ARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC--------------- 249
                |||.|..|..|:|:.|.|:.||||.::.|:|:.|.|..|||||.:|               
Human   137 ----DGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRG 197

  Fly   250 ----------------------------------------------------------------- 249
                                                                             
Human   198 YNQILIVPMGATSILIDEAAASRNFLAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGD 262

  Fly   250 ------------SQPL---------------------------FNWEMAPMSQCSVTCGSGYKMS 275
                        |:||                           |:|.....|.||..||.|:   
Human   263 LAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGH--- 324

  Fly   276 RPICRNRLTNADVD-----DTLCSVTNRPEASVEQCNTHSCP--PRWIADDWSTCSRLCGHGYRE 333
                ::||....:|     |.:|....|| |....||.|.||  .||.|..|:.||..||.|.:.
Human   325 ----QSRLVFCTIDHEAYPDHMCQRQPRP-ADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQS 384

  Fly   334 RMVVC-AEESNGIKTRVADIMCR--TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVE 395
            |.|.| :.:..||:..|.:..|.  ..|||..:.|.::.|..|..|.|..||||||.|::.|.|.
Human   385 RSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVT 449

  Fly   396 CKSTDGSL--SAKCD-----PLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLD 453
            |:...|||  :|.|.     |||:|...:.|                                  
Human   450 CRGERGSLLHTAACSLEDRPPLTEPCVHEDC---------------------------------- 480

  Fly   454 SSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMN 518
                                                  |||               ..:..|:  
Human   481 --------------------------------------PLL---------------SDQAWHV-- 490

  Fly   519 GNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKI-------FLEYSRTVA 576
                                      ..|..||.:|..|.|||...|.|       .|::|:.| 
Human   491 --------------------------GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPV- 528

  Fly   577 TVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFP-RDSIKVGVSEP-------------GKTY 627
                          :||.|...||.||     .:.| ...:....|.|             .:..
Human   529 --------------DVEPCNTQPCHLP-----QEVPSMQDVHTPASNPWMPLGPQESPASDSRGQ 574

  Fly   628 VWREQGYTSCSASCLGGVEELIINCVREDNGRVVS-----PFLCSPETKPEAR----VRTCNDRP 683
            .|..|.:.|......|...:     .|.|.|..:|     |.|..|..:...|    ...|...|
Human   575 WWAAQEHPSARGDHRGERGD-----PRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGPHDCRHSP 634

  Fly   684 ---CP--------PRWNYSDYTPCSKS----CGIGIKTRE----VQCIHEVTRGGDNTMVVPNS- 728
               ||        |:|......||.:|    |...:...|    ..|..  :.|||:|..:|.| 
Human   635 HGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCTK--SYGGDSTGGMPRSR 697

  Fly   729 ------------MCPQPPPADRQ-------YCNV------------------------------- 743
                        ...|..|::.:       |.||                               
Human   698 AVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGEGCVGQPSHAYPVRCLLPSAHGS 762

  Fly   744 -LDCPVRW----EVGE----WSKCSHTCGYGFKDRKVEC-KQIMAQEHKIERPESMCPSA----- 793
             .|...||    .||:    |....|.....|...: || .......|...||:   |.|     
Human   763 CADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQ-ECMSSCQGSLHGPRRPQ---PGASGRST 823

  Fly   794 -------KPA--------------DKKPC--------NVKPCPPEDP------------------ 811
                   .||              .:||.        :.:|.|.|.|                  
Human   824 HTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGGLWRQDQQPGPGEAPHTQAFGEWPWGQELGSRA 888

  Fly   812 --------KPVIQINNSTHIQHDPKKTKITLKVGGAGLV--FFGTQVKIKCPVKRYNRTKIKWSK 866
                    .|....::|::        :|:|......||  ..|..|::.|.......::..|.|
Human   889 PGLGGDAGSPAPPFHSSSY--------RISLAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQK 945

  Fly   867 DHKPLQRSRKYKVSKKGALRILDITFRDAGVYSC---HAGLSSAEISIEVKAKPGQQIEELEQQE 928
            |.:|:. |.::::...|:|.|..:...|||.|||   ..|..|.:|.:.:   .|..:..|.:.|
Human   946 DGQPIS-SDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDSQKIQLRI---IGGDMAVLSEAE 1006

  Fly   929 TERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRR 993
            ..|..:.:.           .|...|.:.|.||...:..|..|..:|.|..|::           
Human  1007 LSRFPQPRD-----------PAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQ----------- 1049

  Fly   994 PKSDGVQHADSSIMEDDLSQLVQSEDR---IPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWP 1055
            |:          :::....|.::...|   .|.||                          :.|.
Human  1050 PR----------VVDASPGQRIRMTCRAEGFPPPA--------------------------IEWQ 1078

  Fly  1056 LQRFKDSRGQHLLQGE--------ALKFG-----IDLSGKDFDQDESE-RVPAE----QLPPEVL 1102
            ......|..:|.||.:        |::.|     :..:|:|.||...: ||..|    .|||.| 
Human  1079 RDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTV- 1142

  Fly  1103 HSPSDPEYHEPSKSGPEADVPH----VPPHMPHARWETG---AAASTTAVPSLPNDGFVYRWMLG 1160
                         :.||.|...    |.....:.||...   ..|....|...| ||.:..:.|.
Human  1143 -------------TVPEGDTARLLCVVAGESVNIRWSRNGLPVQADGHRVHQSP-DGTLLIYNLR 1193

  Fly  1161 EWSQCSQECGA-AGSGLQRRTVSCQRAAKATSSGSTS---DTENNVVDNSECFAHGLELPEFFQS 1221
            ...:.|..|.| .||    :.||.....|..|...|:   |...:.||..|.....|.|..  |.
Human  1194 ARDEGSYTCSAYQGS----QAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQA--QL 1252

  Fly  1222 CGNEACPQWSKGDWTPCQRSHCHGR 1246
            ||||   .:|......|.|...|.:
Human  1253 CGNE---YYSSFCCASCSRFQPHAQ 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 20/50 (40%)
TSP1 546..600 CDD:214559 16/60 (27%)
TSP1 750..807 CDD:214559 18/99 (18%)
IGc2 845..902 CDD:197706 17/59 (29%)
PLAC 1355..1384 CDD:285849
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559 20/50 (40%)
ADAM_spacer1 183..298 CDD:310520 3/114 (3%)
TSP1 308..361 CDD:214559 18/60 (30%)
TSP1 369..424 CDD:214559 17/54 (31%)
TSP1 424..481 CDD:214559 24/128 (19%)
TSP1 488..539 CDD:214559 18/93 (19%)
Kunitz_BPTI 753..805 CDD:278443 10/52 (19%)
Papilin_u7 814..905 CDD:318767 12/93 (13%)
Ig 914..>978 CDD:325142 17/64 (27%)
I-set 1049..1119 CDD:254352 14/116 (12%)
IG 1139..1219 CDD:214652 22/98 (22%)
PLAC 1235..1267 CDD:312271 11/36 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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