DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and THSD7B

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_001303278.1 Gene:THSD7B / 80731 HGNCID:29348 Length:1606 Species:Homo sapiens


Alignment Length:1469 Identity:311/1469 - (21%)
Similarity:469/1469 - (31%) Gaps:582/1469 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 DGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPI-C------RNRLTNADVDDTLCSVTNRP--- 299
            :|...:|  |.|:..|..:|:..||.|...||.: |      .:.|:|       |..:|||   
Human    35 EGKKDNQ--FIWKPGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSN-------CGESNRPPKE 90

  Fly   300 EASVEQCNTHSCPPRWIADDWSTCSRL----------------CGHGYRERMVVCAEESNGIKTR 348
            .:....|:.||...:|...||..|..:                ..||.:.|||.|.::.|  :|.
Human    91 RSCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLN--RTV 153

  Fly   349 VADIMCR--TPKPPTQETCII---EECPHWEVEDWTGCSVSCGQGIQMR-----------GVECK 397
            ||:.:|.  ..:|||::.|:|   .:|...|...|:.||..||:.:|.|           |::|.
Human   154 VANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCP 218

  Fly   398 STDGSLSAKCD-PLTKPGSMQQCSTGIHCG----------GSLNKVGGTIIVGSSRSLNERSERQ 451
            :.  :.|..|| |::.|...::.:..:..|          ..:|..|.|::..:|.| |||...:
Human   219 NL--TESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDS-NERVTFK 280

  Fly   452 LDSSDADEDNEDENDEGDDVDDLESGQDT-------DDGEG--LSYADQ---PLLYAHRTQSRLN 504
            ..|..|...::..        .:|.|..|       .||:.  ||...|   ||    ..||.: 
Human   281 HQSYKAHHHSKSW--------AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPL----TVQSCI- 332

  Fly   505 QEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGE-----GIRRRTYN 564
              .|.:..|...                            :.|||||.||..     |.|.|:.|
Human   333 --MPKDCETSQW----------------------------SSWSPCSKTCRSGSLLPGFRSRSRN 367

  Fly   565 CKIFLEYSRTVATVNDSLCEGKKPHD--EVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTY 627
            .|            :.::..||:..:  |.|.|:.:..:|      .|.||             |
Human   368 VK------------HMAIGGGKECPELLEKEACIVEGELL------QQCPR-------------Y 401

  Fly   628 VWREQGYTSCSAS----------------CLGGVEELIINCVR----------EDNGRVVSPFLC 666
            .||...:..|..|                |.||::...:.|.:          ::..|.|...||
Human   402 SWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALC 466

  Fly   667 ------------------------------------SPETKPEARVR------------------ 677
                                                .|:.|...|.|                  
Human   467 VGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHL 531

  Fly   678 ----TCNDRPCPPRWNYSD--YTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPA 736
                .|.|..| .||..|:  ..|....||:|.:..:..|.::  ||.|    |..|:||.|||.
Human   532 VESVPCEDPMC-YRWLASEGICFPDHGKCGLGHRILKAVCQND--RGED----VSGSLCPVPPPP 589

  Fly   737 DRQYCNV---LDC---------------------------------------------------- 746
            :|:.|.:   :||                                                    
Human   590 ERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL 654

  Fly   747 -------PVRWEVGEWSKCSH-----------------TCGYGFKDRKVEC-----KQIMAQE-H 781
                   .:.||...|..||.                 |||.|.:.|:|.|     .|:|.:. .
Human   655 CNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCP 719

  Fly   782 KIERPESMCPSAKPADKKPCNV------KPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAG 840
            ...|||::.|...|. ||.|.|      .|||     .:.|..|:|..|   .:.:|.::....|
Human   720 DSTRPETVRPCFLPC-KKDCIVTAFSEWTPCP-----RMCQAGNATVKQ---SRYRIIIQEAANG 775

  Fly   841 LVFFGTQ-------------VKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITF 892
                |.:             |.: |||.|:...  |||.                 .:.:.:..:
Human   776 ----GQECPDTLYEERECEDVSL-CPVYRWKPQ--KWSP-----------------CILVPESVW 816

  Fly   893 RDAGV----YSCHAGLSSAEIS-IEVKAKPGQQIEELEQ--------QETERLVREKSGTEALTS 944
            :  |:    .:|..||.:..:| |....:..:.:|.|:|        ||.....||..       
Human   817 Q--GITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDC------- 872

  Fly   945 ADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMED 1009
                      |.||....:..:.:.:...|||||      ..|:.|.:....|           .
Human   873 ----------TFTAWSKFTPCSTNCEATKSRRRQ------LTGKSRKKEKCQD-----------S 910

  Fly  1010 DLSQLVQSE-----DRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQ 1069
            ||..||::|     :.|.||.     |:.:..:|                |..|.:..||..:..
Human   911 DLYPLVETELCPCDEFISQPY-----GNWSDCIL----------------PEGRREPHRGLRVQA 954

  Fly  1070 -----GEALKFGI----DLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHV 1125
                 ||.|:|..    |.:|:                      |.||.:...|....|..|...
Human   955 DSKECGEGLRFRAVACSDKNGR----------------------PVDPSFCSSSGYIQEKCVIPC 997

  Fly  1126 PPHMPHARWET-GAAASTTAV--------------------PSLPNDGFV------------YRW 1157
            |.....:.|.: |:.:|:..:                    |.|.....|            |.|
Human   998 PFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQVHEAVPCYSECNQYSW 1062

  Fly  1158 MLGEWSQC-------SQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLEL 1215
            ::..||.|       |..|   |.|.|.|.:.|.         :|:|.|...||::.|  :..|:
Human  1063 VVEHWSSCKINNELRSLRC---GGGTQSRKIRCV---------NTADGEGGAVDSNLC--NQDEI 1113

  Fly  1216 PEFFQSCGNEACP------QWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSICDEYERP 1274
            |...||| :..||      :|  |.|:.|.:| |...  .||||......|: .....|.|   .
Human  1114 PPETQSC-SLMCPNECVMSEW--GLWSKCPQS-CDPH--TMQRRTRHLLRPS-LNSRTCAE---D 1168

  Fly  1275 AMRQEC-YNERC-EGVWRVEPWSEC----NAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQ--PR 1331
            :..|.| .||.| :..:.:..||.|    ||||| :|::.|:|.||....:..:.:.|:..  .:
Human  1169 SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCG-QGVRTRLLSCVCSDGKPVSMDQCEQHNLEK 1232

  Fly  1332 PAVMKVCKSPAC--QAQLSSSPA-----QLCRDSSRYCR 1363
            |..|.:.....|  ..|||...|     |.|....|..|
Human  1233 PQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSR 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559
TSP1_ADAMTS 256..311 CDD:465950 17/64 (27%)
TSP1_ADAMTS 315..370 CDD:465950 20/75 (27%)
TSP1_ADAMTS 373..420 CDD:465950 15/58 (26%)
TSP1 546..600 CDD:214559 17/60 (28%)
TSP1_ADAMTS 629..684 CDD:465950 18/138 (13%)
TSP1_ADAMTS 688..746 CDD:465950 19/62 (31%)
TSP1_ADAMTS 750..806 CDD:465950 23/84 (27%)
Ig 845..914 CDD:472250 15/86 (17%)
Ig strand B 848..852 CDD:409353 1/3 (33%)
Ig strand C 861..865 CDD:409353 1/3 (33%)
Ig strand E 883..887 CDD:409353 0/3 (0%)
Ig strand F 897..902 CDD:409353 1/8 (13%)
TSP1_ADAMTS 1157..1227 CDD:465950 22/76 (29%)
TSP1_ADAMTS 1289..1343 CDD:465950 16/59 (27%)
PLAC 1355..1384 CDD:462560 3/9 (33%)
THSD7BNP_001303278.1 TSP1_ADAMTS 44..95 CDD:465950 15/57 (26%)
TSP1_spondin 180..229 CDD:465948 14/50 (28%)
TSP1_spondin 337..388 CDD:465948 17/90 (19%)
TSP1_spondin 485..542 CDD:480609 6/56 (11%)
TSP1_spondin 602..660 CDD:465948 1/57 (2%)
TSP1_ADAMTS 665..733 CDD:465950 18/67 (27%)
TSP1_spondin 738..789 CDD:465948 12/62 (19%)
TSP1_ADAMTS 1062..1122 CDD:465950 22/74 (30%)
TSP1_spondin 1128..1174 CDD:480609 14/54 (26%)
TSP1_spondin 1248..1301 CDD:465948 8/24 (33%)
TSP1_spondin 1371..1430 CDD:465948
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1583..1606
Blue background indicates that the domain is not in the aligned region.

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