DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS20

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:XP_011537056.1 Gene:ADAMTS20 / 80070 HGNCID:17178 Length:1911 Species:Homo sapiens


Alignment Length:1517 Identity:294/1517 - (19%)
Similarity:425/1517 - (28%) Gaps:728/1517 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPE-QQDFRSSQ 133
            |:|..|..:|:|||||.|||....|||..|      ..|.|...::|.||...||: .||||..|
Human   558 GEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQ 622

  Fly   134 CSAYN----DVPYDGTLYKWTPHYDYV---EPCALTCR---GHPAHLVEDISRETGDGNAEEAEH 188
            ||.:|    |:....:..:|.|.|..:   :.|.|.|:   .:..:|::|:              
Human   623 CSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDM-------------- 673

  Fly   189 YDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC---- 249
                         |:|||.|.:.:.|:|:||:|...|||..:.|:.|||.|||||||.:||    
Human   674 -------------VEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTIT 725

  Fly   250 -------------------------------SQP------------------------------- 252
                                           .||                               
Human   726 GVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINV 790

  Fly   253 ---------------------------------------------------------LFNWE-MA 259
                                                                     :|.|: ..
Human   791 QGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYG 855

  Fly   260 PMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCS 324
            |...|:..| .|.:.....|.::..::.|.|..|.....|....:.||| .|..||.....|.||
Human   856 PWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCELRWHVIGKSECS 918

  Fly   325 RLCGHGYRERMVVCAEES--NGIKTRVADIMCRTP-KPPTQETCIIEEC--PHWEVEDWTGCSVS 384
            ..||.|||...:.|.:.|  .|...:|.|..|... ||||||.| ...|  ..|...:|:.||.|
Human   919 SQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELC-HGNCVFTRWHYSEWSQCSRS 982

  Fly   385 CGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSE 449
            ||.|.:.|...|.:..|...|                                            
Human   983 CGGGERSRESYCMNNFGHRLA-------------------------------------------- 1003

  Fly   450 RQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTM 514
                      |||.:.                                  .||:.:|        
Human  1004 ----------DNECQE----------------------------------LSRVTRE-------- 1016

  Fly   515 HLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVN 579
                 |.|        |...||.     ..:|||.|.||||:|.::|...|::.:::      ::
Human  1017 -----NCN--------EFSCPSW-----AASEWSECLVTCGKGTKQRQVWCQLNVDH------LS 1057

  Fly   580 DSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGG 644
            |..|......:.:..|....|.                          .|:...:..|:.:|..|
Human  1058 DGFCNSSTKPESLSPCELHTCA--------------------------SWQVGPWGPCTTTCGHG 1096

  Fly   645 VEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCP------------------PRWNYS 691
            .:...:.||.|....|:....|...::|..| ::|...||.                  .:|.:.
Human  1097 YQMRDVKCVNELASAVLEDTECHEASRPSDR-QSCVLTPCSFISKLETALLPTVLIKKMAQWRHG 1160

  Fly   692 DYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQ-PPPADRQYCNVLDC--PV-RWEV 752
            .:||||.|||.|.:.|.|.|...:.|      :...|.|.. |.||:     :.||  |. .|:.
Human  1161 SWTPCSVSCGRGTQARYVSCRDALDR------IADESYCAHLPRPAE-----IWDCFTPCGEWQA 1214

  Fly   753 GEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMC-PSAKPADKKPCNVKPCPPEDPKPVIQ 816
            |:||.||.:||:|...|:|.|   |.....|:  |:.| |..:|..::.|::..|||        
Human  1215 GDWSPCSASCGHGKTTRQVLC---MNYHQPID--ENYCDPEVRPLMEQECSLAACPP-------- 1266

  Fly   817 INNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSK 881
                                                                             
Human  1267 ----------------------------------------------------------------- 1266

  Fly   882 KGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSAD 946
                              .|:...|:.:                                     
Human  1267 ------------------AHSHFPSSPV------------------------------------- 1276

  Fly   947 MKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDL 1011
                                                                             
Human  1277 ----------------------------------------------------------------- 1276

  Fly  1012 SQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFG 1076
                       ||:                |:  |.:||.|   .|:.:|:..|           
Human  1277 -----------QPS----------------YY--LSTNLPL---TQKLEDNENQ----------- 1298

  Fly  1077 IDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETGAAAS 1141
                                    |:|         ||..|.:                      
Human  1299 ------------------------VVH---------PSVRGNQ---------------------- 1308

  Fly  1142 TTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNS 1206
                           |..|.|..||..|   ..|||.|.|.||             .||.   .|
Human  1309 ---------------WRTGPWGSCSSSC---SGGLQHRAVVCQ-------------DENG---QS 1339

  Fly  1207 ECFAHGLELPEFFQSCGNEACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNG--TEGSICD 1269
            ..:......|...|.||...||||:.|:|..|.:: |.|   .::.|.|.|::|||  .|...|:
Human  1340 ASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQT-CGG---GIKSRLVICQFPNGQILEDHNCE 1400

  Fly  1270 EYERPAMRQECYNERC--EGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRP 1332
            ...:|....:|:...|  :..|..|||:.|:|.|| ||.|||.:.|:....|:.....|....:|
Human  1401 IVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCG-KGRKYREVFCIDQFQRKLEDTNCSQVQKP 1464

  Fly  1333 AVMKVCKSPACQAQLSSS---------------------------PAQLCRDSSRYCRNARAMGL 1370
            ...|.|:|..|.:..::|                           ..::|..|:|.|...|....
Human  1465 PTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQ 1529

  Fly  1371 -CRLH----RYKLKCCGSCEQQ 1387
             |..|    |.:|.|..|||::
Human  1530 DCVQHKGMERGRLNCSTSCERK 1551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 20/51 (39%)
TSP1 546..600 CDD:214559 14/53 (26%)
TSP1 750..807 CDD:214559 19/57 (33%)
IGc2 845..902 CDD:197706 0/56 (0%)
PLAC 1355..1384 CDD:285849 10/33 (30%)
ADAMTS20XP_011537056.1 Pep_M12B_propep 64..185 CDD:279848
Reprolysin 259..467 CDD:279729
ZnMc_ADAMTS_like 259..464 CDD:239801
TSP1 560..612 CDD:214559 20/51 (39%)
ADAM_spacer1 722..841 CDD:283607 2/118 (2%)
TSP1 971..1024 CDD:214559 21/161 (13%)
TSP1 1029..1078 CDD:214559 14/54 (26%)
TSP1 1081..1136 CDD:214559 13/55 (24%)
TSP1 1160..>1183 CDD:214559 11/22 (50%)
TSP1 1209..1265 CDD:214559 19/60 (32%)
TSP1 1363..1417 CDD:214559 16/57 (28%)
TSP_1 1483..1526 CDD:301595 4/42 (10%)
GON 1715..1910 CDD:285848
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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