DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and THSD4

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_001381461.1 Gene:THSD4 / 79875 HGNCID:25835 Length:1018 Species:Homo sapiens


Alignment Length:1140 Identity:203/1140 - (17%)
Similarity:295/1140 - (25%) Gaps:609/1140 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 KRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRC-------------GSPG--- 106
            :|...:.|....|.||.||.|.:|..||.|||:|.||:|.|.|.|             |:|.   
Human    36 QRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARAF 100

  Fly   107 ----------------------------------------------------------------- 106
                                                                             
Human   101 ADHVVSAVRTSVPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPG 165

  Fly   107 ----------------------------------------------------------------- 106
                                                                             
Human   166 KYGYGKAPYILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSG 230

  Fly   107 -----------------------------------------------------------SCRGES 112
                                                                       ||.|..
Human   231 PRSGLQAAEAPIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAY 295

  Fly   113 TRYRICNMQPCPE-QQDFRSSQCSAYNDVPYDGTLYKWTPHYDYV--EPCALTCRGHPAHLVEDI 174
            .:|::||...||| .:..|..||::||:.|:.|..|:|.|..:..  ..|.|.|           
Human   296 RQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNC----------- 349

  Fly   175 SRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGC 239
                      :|..|   ...|:.:.:|.|||.|......:|:.|:|:.:|||..:||.|.:|.|
Human   350 ----------QAMGY---RFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKC 401

  Fly   240 GVCGGDGNSC------------------------------------------------------- 249
            ||||||...|                                                       
Human   402 GVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGN 466

  Fly   250 ------------------------------------------------SQP-------------- 252
                                                            .||              
Human   467 WAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTN 531

  Fly   253 ------------------------------------------------LF--------------- 254
                                                            :|               
Human   532 AISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDR 596

  Fly   255 -----------------------NWEMAPMSQCSVTCGSG--YKMSRPICRNRLTNADVDDTLCS 294
                                   ||:....::||.|||.|  |.:.|  |.:|.|:.:..::.|.
Human   597 FSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFR--CVHRSTHEEAPESYCD 659

  Fly   295 VTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR-TPK 358
            .:.:|....|.||...||..|...:||.||:.||.|.:.|.|:|.:........|....|: ..|
Human   660 SSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEK 724

  Fly   359 PPTQETCIIEECPHWEVE-DWTGCSVSCGQGIQMRGVECKSTDGSL--SAKCDPLTKPGSMQQCS 420
            |.|..||.::.|..|::. |||.|||.||.|.:.|.|:|.|..|.:  ..:|:...:|..::.|.
Human   725 PETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCD 789

  Fly   421 TGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEG 485
            .| .|             ..|..|.|.|||                                   
Human   790 MG-PC-------------AKSWFLTEWSER----------------------------------- 805

  Fly   486 LSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPC 550
                                                                            |
Human   806 ----------------------------------------------------------------C 806

  Fly   551 SVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDS 615
            |..||.|:|.|:..|     .:..|:::....|...:| .|...|...||               
Human   807 SAECGAGVRTRSVVC-----MTNHVSSLPLEGCGNNRP-AEATPCDNGPC--------------- 850

  Fly   616 IKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVRE--DNGRVVSPFLCSPETKPEARVRT 678
                   .||. .|....::.||..|..|.::..:.|||:  |...|:.|..||...||.:: ::
Human   851 -------TGKV-EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQ-QS 906

  Fly   679 CNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNV 743
            |:.:||..:|..::::.|||||..|.:.|||:|:       .:.|.:.|...||..|.:|:.||.
Human   907 CHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL-------SDDMTLSNLCDPQLKPEERESCNP 964

  Fly   744 LDC-PVRWEVGEWSKCSHTCGYGFKDRKVECKQIM 777
            .|| |   ||.|      .|    ||:...|..::
Human   965 QDCVP---EVDE------NC----KDKYYNCNVVV 986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 22/250 (9%)
TSP1 546..600 CDD:214559 13/53 (25%)
TSP1 750..807 CDD:214559 7/28 (25%)
IGc2 845..902 CDD:197706
PLAC 1355..1384 CDD:285849
THSD4NP_001381461.1 TSP1 58..>95 CDD:214559 13/36 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..235 0/123 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..279 0/24 (0%)
ADAM_spacer1 412..528 CDD:368694 2/115 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..623 3/88 (3%)
TSP1_ADAMTS 627..676 CDD:408800 16/50 (32%)
TSP1_ADAMTS 680..736 CDD:408800 18/55 (33%)
TSP1_ADAMTS 739..793 CDD:408800 19/54 (35%)
TSP1_ADAMTS 797..850 CDD:408800 18/157 (11%)
TSP1_ADAMTS 856..912 CDD:408800 16/56 (29%)
TSP1_ADAMTS 916..967 CDD:408800 19/57 (33%)
PLAC 975..1005 CDD:400844 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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