DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nolo and Adamts1

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_077376.2 Gene:Adamts1 / 79252 RGDID:621241 Length:967 Species:Rattus norvegicus


Alignment Length:447 Identity:125/447 - (27%)
Similarity:173/447 - (38%) Gaps:141/447 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCPEQ--QDFRSS 132
            |.|..|..|..|||||.||:.:.||.|.:|     |. |.|:..|||.||::.||:.  :.||..
  Rat   560 GSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREE 624

  Fly   133 QCSAYNDVPY----DGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHYD 190
            ||.|:|:...    :....:|||.|..|.|   |.|||..            .|.|         
  Rat   625 QCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEA------------KGIG--------- 668

  Fly   191 EQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFN 255
               ....|..:|.|||.|...|..:|:||:|.:.|||..|.|.||.|.||||||:|::|.:    
  Rat   669 ---YFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKK---- 726

  Fly   256 WEMAPMSQCSVTCGSGY---------------KMSRPICRNRLTNAD------VDDTLCSVTNRP 299
                 :|....:...||               |...|  |....|..      .|.|.....|..
  Rat   727 -----ISGTVTSTRPGYHDIVTIPAGATNIEVKHRNP--RGSRNNGSFLAIRAADGTYILNGNFT 784

  Fly   300 EASVEQCNT------------------------------------HSCPPR-------------- 314
            .:::||..|                                    |:..|:              
  Rat   785 LSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKYTYFMKKKTEPF 849

  Fly   315 --------WIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECP 371
                    |:.::|..||:.||.|::.|:|.|.:    |....|....:..||.:...|....||
  Rat   850 NAIPTFSEWVIEEWGECSKTCGSGWQRRVVECRD----INGHPASECAKEVKPASTRPCADLPCP 910

  Fly   372 HWEVEDWTGCSVSCGQGIQMRGVECKSTDGSL--SAKCDPLTKPGS------MQQCS 420
            .|:|.||:.||.:||:|.:.|.::|.|.||.:  :..||||.||..      :.|||
  Rat   911 RWQVGDWSPCSKTCGKGYKKRTLKCLSHDGGVLSNESCDPLKKPKHYIDFCILTQCS 967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 22/51 (43%)
TSP1 546..600 CDD:214559
TSP1 750..807 CDD:214559
IGc2 845..902 CDD:197706
PLAC 1355..1384 CDD:285849
Adamts1NP_077376.2 Pep_M12B_propep 67..168 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..252
Cysteine switch. /evidence=ECO:0000250 203..210
Reprolysin 258..467 CDD:279729
ZnMc_ADAMTS_like 258..463 CDD:239801
ADAM_CR 468..548 CDD:301627
ADAM_CR 529..698 CDD:301627 54/161 (34%)
TSP1 562..614 CDD:214559 22/51 (43%)
Spacer 725..857 15/142 (11%)
ADAM_spacer1 725..842 CDD:283607 15/127 (12%)
TSP1 856..910 CDD:214559 15/57 (26%)
TSP1 912..>953 CDD:214559 18/40 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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