DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and Adamtsl2

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_084257.1	Gene:	Adamtsl2 / 77794	MGIID:	1925044	Length:	957	Species:	Mus musculus

Alignment Length:	1195	Identity:	220/1195 - (18%)
Similarity:	303/1195 - (25%)	Gaps:	652/1195 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NWTSPKIWAALFVTTLCLLDTQAAWAKKLNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGG 70
            :|.    |:.|.|..:      |..|....||    |...|::.||                 ||
Mouse     9 HWA----WSLLAVAVV------AGGAAPTEAS----DNSPTSNSLE-----------------GG 42

  Fly    71 AGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRC------GSPG----SCRGESTRYRICNMQPC-P 124
            |......|..|:.|:.|||:|.||:..|.|.|      ..||    :|.|.|.||::|.:|.| |
Mouse    43 ADTTAYWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGTGNRTCVGTSKRYQLCRVQECPP 107

  Fly   125 EQQDFRSSQCSAYNDVPYDGTLYKWTPHY--DYV----EPCALTCRGHPAHLVEDISRETGDGNA 183
            :.:.||..||.::|...|||..|:|.|.|  |||    :||.|.|             .|.||..
Mouse   108 DGRSFREEQCVSFNSRVYDGRAYQWKPLYPDDYVHISSKPCDLHC-------------STVDGQR 159

  Fly   184 EEAEHYDEQSVIVQLSARVQDGTRCRSGSL-DMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGN 247
                         ||:...:|||.|:...| .:|:.|||:.:|||..:.||..:|.||||.|||:
Mouse   160 -------------QLTVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGS 211

  Fly   248 SCS-------------------------------------------------------------- 250
            ||:
Mouse   212 SCTHVTGNYRKGNNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKN 276

  Fly   251 ----------------------------------------------------------------- 250

Mouse   277 FNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQSPHMHHLPP 341

  Fly   251 ----------------------------------------------------QP----------- 252
                                                                ||
Mouse   342 VYYSFSEAASQSTESTERQELDSARLLGFMQHNGSLYRQTSSERLGLNSQLFQPPAPEVELGPSR 406

  Fly   253 ----------------------------------------------------------------- 252

Mouse   407 GQESNEVCKQASGGVCEGPPRGKGFQDHNATGRAFSADKDDREISAHFTSHELLSANTISDQLLG 471

  Fly   253 ----------------------------------------------------------------- 252

Mouse   472 TGSESEEFSLNETMNSIFAQGAPRSSPAESLYVDYEENEGPAAYLINGSYLELSSDRINTSSEAP 536

  Fly   253 ----------------------------------LFNWEMAPMSQCSVTCGSGYKMSRPICRNRL 283
                                              ::.|:::....||.||.:|...:..:| .|.
Mouse   537 FPNTSASPPNLAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSTYAMC-VRY 600

  Fly   284 TNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEE-SNGIKT 347
            ...:|||:.|....|||...|.|....|.|||....||.|||.||.|::.|:|.|.:. |.|..:
Mouse   601 DGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDS 665

  Fly   348 RVADIMCRTP---KPPTQETCIIEEC-PHWEVEDWTGCSVSCGQ-GIQMRGVECKSTDGSLSAKC 407
            .|...:|...   :|..::||....| |.||:.:|:.|:..||: .:..|.:.| |.|..|   |
Mouse   666 SVYSDLCEATEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC-SEDEKL---C 726

  Fly   408 DPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVD 472
            ||.|||...:.| ||..|                       :||...||
Mouse   727 DPSTKPVGEKNC-TGPPC-----------------------DRQWTVSD---------------- 751

  Fly   473 DLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSL 537

Mouse   752 ----------------------------------------------------------------- 751

  Fly   538 DPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCML 602
                     |.|||.:||:|...|...||
Mouse   752 ---------WGPCSGSCGQGRTIRHVYCK------------------------------------ 771

  Fly   603 PSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCS 667
                                            ||                    :||||....|.
Mouse   772 --------------------------------TS--------------------DGRVVPESQCQ 784

  Fly   668 PETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQ 732
            .||||.| :..|.|:.||..|...|:..|:.:||.|:|.|.|.|: |:..|.......|.....:
Mouse   785 TETKPLA-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCM-ELANGKPQIRSGPECGLAR 847

  Fly   733 PPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPAD 797
            .|| :...|....| .:|....||:|:.|||.|.:.|.|:|.|      ..:......|..||..
Mouse   848 KPP-EESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ------GTDIVRGCDPLVKPVG 904

  Fly   798 KKPCNVKPCPPEDPKPVIQINNSTH 822
            ::.|:::|||.|.|....|....|:
Mouse   905 RQACDLQPCPTEPPDDSCQDQPGTN 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/56 (39%)
		TSP1	546..600	CDD:214559	10/53 (19%)
		TSP1	750..807	CDD:214559	17/56 (30%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamtsl2	NP_084257.1	TSP1	50..106	CDD:214559	21/55 (38%)
		ADAM_spacer1	216..330	CDD:368694	0/113 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..568		0/35 (0%)
		TSP1_ADAMTS	632..691	CDD:408800	19/58 (33%)
		TSP1_ADAMTS	695..743	CDD:408800	20/52 (38%)
		TSP1_ADAMTS	747..800	CDD:408800	26/231 (11%)
		TSP1_ADAMTS	804..860	CDD:408800	16/57 (28%)
		TSP1_ADAMTS	863..913	CDD:408800	16/55 (29%)
		PLAC	922..953	CDD:400844	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900