DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and ADAMTS9

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_891550.1 Gene:ADAMTS9 / 56999 HGNCID:13202 Length:1935 Species:Homo sapiens


Alignment Length:1594 Identity:332/1594 - (20%)
Similarity:472/1594 - (29%) Gaps:676/1594 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.|||.:.||||||.|||...:|.|..|..      |.|...:::.||.:||.:| :|||..|
Human   589 GSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQ 653

  Fly   134 CSAYNDVPY--DGTL--YKWTPHYDYV---EPCALTCR--GHPAHLVEDISRETGDGNAEEAEHY 189
            |:.::...:  :|.|  .:|.|.|..:   :.|.|.||  |:.|:                    
Human   654 CAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAY-------------------- 698

  Fly   190 DEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQ--- 251
                  .||..||.|||.|...:.|:|:||.|::.|||..:.|..:.|.|||||||.:||..   
Human   699 ------YQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAG 757

  Fly   252 ----------------------------------------------------------------- 251
                                                                             
Human   758 TFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRI 822

  Fly   252 ------------------------------------------------PL------FNWEM-APM 261
                                                            |:      |.|.. .|.
Human   823 GNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPW 887

  Fly   262 SQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRL 326
            ..||..| .|.:..:.:|........|.|..|....:|....|.|.| .|..||.....|.||..
Human   888 QACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGT-DCDLRWHVASRSECSAQ 950

  Fly   327 CGHGYRERMVVCAEES--NGIKTRVADIMCRT-PKPPTQETCIIEEC--PHWEVEDWTGCSVSCG 386
            ||.|||...:.||:.|  :|...:|.|..|.: |||..:|.| ..||  ..|....||.||.||.
Human   951 CGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKC-SGECNTGGWRYSAWTECSKSCD 1014

  Fly   387 QGIQMRGVECKSTDGSL--SAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSE 449
            .|.|.|...|.:|...:  .:||....|. ::|:|                              
Human  1015 GGTQRRRAICVNTRNDVLDDSKCTHQEKV-TIQRC------------------------------ 1048

  Fly   450 RQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTM 514
                                                                             
Human  1049 ----------------------------------------------------------------- 1048

  Fly   515 HLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVN 579
                             ||.|.  |.: |..:||.|.||||:|.:.|...|:...:      .:|
Human  1049 -----------------SEFPC--PQW-KSGDWSECLVTCGKGHKHRQVWCQFGED------RLN 1087

  Fly   580 DSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGG 644
            |.:|:.:.....::.|.:..|.                          .|:...:..||.:|..|
Human  1088 DRMCDPETKPTSMQTCQQPECA--------------------------SWQAGPWGQCSVTCGQG 1126

  Fly   645 VEELIINCVREDNGRVVSPFLCSPETKP----EARVRTCNDRPCPP------------RWNYSDY 693
            .:...:.|:......||....|:..|:|    :..:.:|:..|..|            :|.:..:
Human  1127 YQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSW 1191

  Fly   694 TPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQ-PPPADRQYCNVLDCPVRWEVGEWSK 757
            ||||.:||.|.:.|.|.|..|      |..|...|.|.. |.|..::.|:|..|. :|:..:||.
Human  1192 TPCSATCGKGTRMRYVSCRDE------NGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSS 1249

  Fly   758 CSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAK-PADKKPCNVKPCPPEDPKPVIQINNST 821
            ||.|||.|...|:|.|  :...:|.|:|.|  |.... |...:.|::.|||...|       :|.
Human  1250 CSVTCGQGRATRQVMC--VNYSDHVIDRSE--CDQDYIPETDQDCSMSPCPQRTP-------DSG 1303

  Fly   822 HIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALR 886
            ..||                           |.:         ::|::|  ||            
Human  1304 LAQH---------------------------PFQ---------NEDYRP--RS------------ 1318

  Fly   887 ILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSAD 951
                                        |.|                   |.|..|.....::..
Human  1319 ----------------------------ASP-------------------SRTHVLGGNQWRTGP 1336

  Fly   952 -GTGTSTAVGPNSHVNGSAQQHGSRRRQQ--QSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQ 1013
             |..:||..|            ||:||..  |.|......:...|.|.|..:..:|.        
Human  1337 WGACSSTCAG------------GSQRRVVVCQDENGYTANDCVERIKPDEQRACESG-------- 1381

  Fly  1014 LVQSEDRIPQPASA----------SSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLL 1068
                    |.|..|          ..||.|||.::.                             
Human  1382 --------PCPQWAYGNWGECTKLCGGGIRTRLVVC----------------------------- 1409

  Fly  1069 QGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHAR 1133
                            .:...||.|  .|..|:|..|.|.|...          .|..||  .|.
Human  1410 ----------------QRSNGERFP--DLSCEILDKPPDREQCN----------THACPH--DAA 1444

  Fly  1134 WETGAAASTTA----------VPSLPNDGF-----------------------VYRWMLGEWSQC 1165
            |.||..:|.:.          |..:..||.                       ..:|..|.||||
Human  1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQC 1509

  Fly  1166 SQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACP-- 1228
            |..|   |.|:|:|.|.||...            :.:...:||  :....||..:.|....||  
Human  1510 SVSC---GRGVQQRHVGCQIGT------------HKIARETEC--NPYTRPESERDCQGPRCPLY 1557

  Fly  1229 QWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTE--GSICDEYERPAMRQECYNERCEGVWRV 1291
            .|...:|..|.::...|    .:.|:|.|...|..|  |:.||..:||..|:.|..:.||.||..
Human  1558 TWRAEEWQECTKTCGEG----SRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWIT 1618

  Fly  1292 EPWSECNAPCGRKGIKYRILQCVWY------------------GSRRPAGNVC--KHQPRPAVMK 1336
            ..||||:..|| ||.|.|::.|...                  |::.|:.:.|  :..|..|..:
Human  1619 GEWSECSVTCG-KGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWR 1682

  Fly  1337 VCKSPACQAQL--------------SSSPAQLCR-----DSSRYCRNA-------------RAMG 1369
            |....:|....              ...|:.||.     :..:.|||.             |..|
Human  1683 VGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKG 1747

  Fly  1370 LCRLHRY---------KLKCCGSCEQQPNQHLIL 1394
            ......|         |:.|.|.....|.:::.|
Human  1748 ASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTL 1781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 21/51 (41%)
TSP1 546..600 CDD:214559 14/53 (26%)
TSP1 750..807 CDD:214559 20/57 (35%)
IGc2 845..902 CDD:197706 5/56 (9%)
PLAC 1355..1384 CDD:285849 10/55 (18%)
ADAMTS9NP_891550.1 Pep_M12B_propep 73..206 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..242
Cysteine switch. /evidence=ECO:0000250 221..228
Reprolysin 293..499 CDD:279729
ZnMc_ADAMTS_like 293..496 CDD:239801
TSP1 591..642 CDD:214559 20/50 (40%)
Spacer 753..877 1/123 (1%)
ADAM_spacer1 753..871 CDD:283607 0/117 (0%)
TSP1 1001..1054 CDD:214559 20/167 (12%)
TSP1 1059..1103 CDD:214559 13/49 (27%)
TSP1 1114..1166 CDD:214559 10/51 (20%)
TSP1 1186..1239 CDD:214559 20/58 (34%)
TSP1 1239..1296 CDD:214559 21/61 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1330 18/144 (13%)
TSP1 1332..1384 CDD:214559 15/79 (19%)
TSP1 1386..1440 CDD:214559 16/110 (15%)
TSP1 1445..1499 CDD:214559 7/53 (13%)
TSP1 1504..1555 CDD:214559 19/67 (28%)
TSP1 1562..1613 CDD:214559 15/54 (28%)
TSP1 1615..1676 CDD:214559 16/61 (26%)
GON 1738..1934 CDD:285848 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11783
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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