Protein Alignment nolo and adamts15a

DIOPT Version :10

• Sequence 1: NP_001036374.1
• Gene: nolo / 35424
• FlyBaseID: FBgn0051619
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_001119901.1
• Gene: adamts15a / 569571
• ZFINID: ZDB-GENE-060526-203
• Length: 958
• Species: Danio rerio
• Alignment Length: 706
• Identity: 161/706 - (22%)
• Similarity: 239/706 - (33%)
• Gaps: 295/706 - (41%)

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |:|..|..:.:|||||.||:....|.|.:|     |. |:|...:||.||:.|||:. :.:|..|
Zfish   512 GKWGKWGPFGSCSRTCGGGVQLSKRECDNPVPVNGGKYCQGVRVKYRSCNLSPCPDTGKSYREEQ 576

  Fly   134 CSAYNDVPYD----GTLYKWTPHYDYV---EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDE 191
            |.|||....:    .:...|.|.|..|   :.|.|.||.:            |.|
Zfish   577 CEAYNGFSLNTNRLTSSVVWVPKYSGVSAKDMCKLICRAN------------GTG---------- 619

  Fly   192 QSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------- 249
              ....|:.:|.|||.|...|..:|:||||.:.|||.|:||.||.|.|||||||..:|
Zfish   620 --YFYVLAPKVVDGTPCSPDSSSVCVQGKCIKAGCDGKLGSNKKSDKCGVCGGDNKNCKKVSGLF 682

  Fly   250 SQPLFNWE---MAPMSQCSVTCGS-GYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHS 310
            ::|:..:.   |.||...::.... |||        .:|:   ||...:|.|.....:...|
Zfish   683 TKPMHGYNFVVMLPMGSSNIDIRQRGYK--------GITS---DDNYLAVKNNQGKYLLNGN--- 733

  Fly   311 CPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEV 375
                                    .||.|.|.        ||:.:
Zfish   734 ------------------------YVVSAMEK--------DILVK-------------------- 746

  Fly   376 EDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGS 440
                                                               |||.:..||  |||
Zfish   747 ---------------------------------------------------GSLLRYSGT--VGS 758

  Fly   441 SRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQ 505
            |.:|  ::.:.|             .|...::.|..||.|......|:      |..| :|:.|:
Zfish   759 SETL--QAVKPL-------------GEALIIEVLSVGQMTPPRIRYSF------YLPR-ESKDNK 801

  Fly   506 EAPDEPRTMHLMNGNSNNNF-------NRGEDESE--GPSLDPTYIKDNEWSPCSVTCGEGIRRR 561
            ....|.:      ..:.|:.       |:|..|::  ...:.|.|:||
Zfish   802 AQKKEEK------ARAENSILREEGGVNKGGKEADILKDKIAPAYVKD----------------- 843

  Fly   562 TYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKT 626
                         :|                                            |:|||
Zfish   844 -------------IA--------------------------------------------SKPGK- 850

  Fly   627 YVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYS 691
              |...|:..||.:|..|::..::.|:..|.|..|.   |.|..||.| ::.|.| || |.|:..
Zfish   851 --WVAAGWDVCSVTCGNGLQRRMVQCLGGDGGPGVD---CEPSQKPSA-IQACGD-PC-PMWDVG 907

  Fly   692 DYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPADRQYCNVLDC 746
            |::||||:||.|.|.|.::||..|.:      ::|...| .:..|.:..:|::..|
Zfish   908 DWSPCSKTCGKGFKRRLLRCITTVGK------LLPREKCVDKKKPQELDFCSLAPC 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	20/51 (39%)
		TSP1_ADAMTS	256..311	CDD:465950	12/58 (21%)
		TSP1_ADAMTS	315..370	CDD:465950	6/54 (11%)
		TSP1_ADAMTS	373..420	CDD:465950	0/46 (0%)
		TSP1	546..600	CDD:214559	1/53 (2%)
		TSP1_ADAMTS	629..684	CDD:465950	17/54 (31%)
		TSP1_ADAMTS	688..746	CDD:465950	18/58 (31%)
		TSP1_ADAMTS	750..806	CDD:465950
		Ig	845..914	CDD:472250
		Ig strand B	848..852	CDD:409353
		Ig strand C	861..865	CDD:409353
		Ig strand E	883..887	CDD:409353
		Ig strand F	897..902	CDD:409353
		TSP1_ADAMTS	1157..1227	CDD:465950
		TSP1_ADAMTS	1289..1343	CDD:465950
		PLAC	1355..1384	CDD:462560
adamts15a	NP_001119901.1	Pep_M12B_propep	30..151	CDD:460254
		ZnMc_ADAMTS_like	212..418	CDD:239801
		ADAMTS_CR_2	432..500	CDD:465496
		TSP1	514..566	CDD:214559	20/51 (39%)
		ADAMTS_CR_3	568..675	CDD:437068	44/130 (34%)
		ADAMTS_spacer1	677..794	CDD:461796	37/256 (14%)
		TSP1_ADAMTS	851..901	CDD:465950	17/54 (31%)
		TSP1_ADAMTS	904..957	CDD:465950	18/58 (31%)